UTMB Health SHARED
UTMB Health SHARED is an online community space for Scholarship, Historical Archives, Repository, & Electronic Dissertations. This digital service is an important tool for preserving the organization’s legacy and facilitating scholarly communication.

Communities in UTMB Health SHARED
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HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
(2020-08-01)Chronic HCV infection is the leading cause of steatosis (fatty liver disease) and hepatocellular carcinoma (HCC). The virus establishes a chronic infection in 70% of patients and infects approximately 71 million people ... -
Proviral Roles of Ebola virus VP35 Ubiquitination
(2022-05-01)Ebola virus’ structural protein VP35 is polyfunctional and plays vital roles in Ebola’s life cycle from antagonizing the host’s type I interferon pathway to acting as the polymerase co-factor. The mechanisms that regulate ... -
Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors
(2021-05-01)The discovery of G protein-coupled receptors (GPCRs) and the extensive second messenger systems associated with their activation has ushered in an enormously productive period in drug discovery. The extent to which around ... -
Opioid Prescribing and Opioid-Related Health Outcomes Among Cancer Survivors
(2023-05-01)The US population of older long-term cancer survivors—Americans who are free of cancer 5-years post-cancer diagnosis and not receiving cancer treatment—is growing. The prevalence of pain among cancer survivors after curative ... -
Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions
(2020-05-01)As fundamental determinants of neuronal function, voltage-gated Na+ (Nav) channels are important targets for therapeutic development against a wide range of health conditions. Dysfunction of Nav channels in the CNS is ...