UTMB Health SHARED
UTMB Health SHARED is an online community space for Scholarship, Historical Archives, Repository, & Electronic Dissertations. This digital service is an important tool for preserving the organization’s legacy and facilitating scholarly communication.
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
Addictive disorders are a collection of maladaptive behaviors characterized by the uncontrolled use of a rewarding substance. These include substance use disorders, binge eating disorder, certain subtypes of obesity, ... -
Modulation of Host BRD4 to Repress HIV Replication in Myeloid Cells: Major HIV Reservoirs in Central Nervous System
Brain-resident microglia and myeloid cells (perivascular macrophages) are important HIV reservoirs in vivo, especially in central nerve system (CNS). Despite anti-retroviral therapy (ART), low-level persistent HIV replication ... -
Ehrlichia chaffeensis E3 Ligase TRP120 Ubiquitinates Tumor Suppressor FBW7 for Degradation to Promote Infection
Ehrlichia chaffeensis (E. chaffeensis) exploits evolutionarily conserved Notch and Wnt host cell signaling pathways to downregulate innate immune host defenses and promote infection. The multifunctional E. chaffeensis ... -
Rickettsia prowazekii and its ‘Junk DNA’: The Identification and Characterization of Small RNAs
As the etiologic agents of Rocky Mountain spotted fever and epidemic typhus, Rickettsia are obligate intracellular Gram-negative pathogenic bacteria. Genomic sequencing determined that ~24% of the Rickettsia prowazekii ... -
Outcomes of Selective Percutaneous Myofascial Lengthening Surgery (SPML) In Children with Lower Extremity Spasticity
Cerebral palsy (CP) is a neurodevelopmental condition defined as a disorder of posture and movement that is caused by a nonprogressive abnormality of an immature brain which can result in spasticity (Paneth, 2006; Pelligrino, ...
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