• HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner 

  Hull, Madeleine E (2020-08-01)

  Chronic HCV infection is the leading cause of steatosis (fatty liver disease) and hepatocellular carcinoma (HCC). The virus establishes a chronic infection in 70% of patients and infects approximately 71 million people ...

• Proviral Roles of Ebola virus VP35 Ubiquitination 

  Van Tol, Sarah Rose (2022-05-01)

  Ebola virus’ structural protein VP35 is polyfunctional and plays vital roles in Ebola’s life cycle from antagonizing the host’s type I interferon pathway to acting as the polymerase co-factor. The mechanisms that regulate ...

• Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors 

  Wold, Eric A. (2021-05-01)

  The discovery of G protein-coupled receptors (GPCRs) and the extensive second messenger systems associated with their activation has ushered in an enormously productive period in drug discovery. The extent to which around ...

• Opioid Prescribing and Opioid-Related Health Outcomes Among Cancer Survivors 

  Gibson, Derrick C (2023-05-01)

  The US population of older long-term cancer survivors—Americans who are free of cancer 5-years post-cancer diagnosis and not receiving cancer treatment—is growing. The prevalence of pain among cancer survivors after curative ...

• Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions 

  Wadsworth, Paul A (2020-05-01)

  As fundamental determinants of neuronal function, voltage-gated Na+ (Nav) channels are important targets for therapeutic development against a wide range of health conditions. Dysfunction of Nav channels in the CNS is ...

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