Browsing by Author "Jackson, George R"
Now showing items 1-7 of 7
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Autophagy gridlock in tauopathy
Bakhoum, Mathieu 1985-Tauopathies are a group of neurodegenerative diseases characterized by the presence of intracellular aggregates containing the microtubule associated protein tau. Bulk degradation of aggregation-prone proteins can occur ... -
Characterization of Codon Optimized Wild Type TDP-43 Mediated Neurodegeneration in a Drosophila Model for ALS.
Yusuff, TanzeenTAR DNA Binding Protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration-ubiquitin (FTLD-U). The exact mechanism by which TDP-43 ... -
Molecular Pathogenesis of Spinocerebellar Ataxia type 10
Lim, Jung gook 1971- (2013-06-03)Spinocerebellar ataxia type 10 (SCA10) is a unique autosomal dominant cerebellar ataxia (ADCA) which habors non-coding ATTCT repeat expansion on the 9th intron of the ATXN10 gene. The presence of seizure in addition to ... -
Molecular Pathogenesis of Spinocerebellar Ataxia type 10
Lim, Jung gook (2013-06-03)Microsatellite plays a major pathogenic role in repeat expansion disorder. This heterogeneous group of disease is caused by the expanded sequences of nucleotide repeat within a target gene. Spinocerebellar ataxia type 10 ... -
New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis
Stieren, Emily 1980-Alzheimer’s disease (AD) is the most common form of age-related dementia. Our current understanding of AD pathogenesis is largely based on data from cases of relatively rare early-onset forms of the disease, collectively ... -
TDP-43 and its role in neurodegeneration
Choksi, Darshana 1975-Ubiquitinated TDP-43 (TAR DNA Binding Protein) inclusions are a hallmark of ALS (amyotrophic lateral sclerosis) and FTLD-TDP-43 (frontotemporal lobar degeneration with ubiquitin inclusions). These diseases share a similar ... -
The Role of Sacsin as a Molecular Chaperone
Anderson, John (2013-06-03)The central pathological finding in neurodegenerative disease is loss of neurons. In many disorders, this loss of neurons appears to be related to protein misfolding, comprising a large public health burden. For example, ...