Browsing by Author "Valbuena, Gustavo"
Now showing items 1-12 of 12
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CD4+ T cells in the pathogenesis of visceral leishmaniasis
Medina, Audrie A; 0000-0002-4917-666XVisceral leishmaniasis, caused by infection with the intracellular protozoan Leishmania donovani, is a chronic disease that affects the spleen, liver and bone marrow. Patients present with high parasite burdens in visceral ... -
Characterization of the Burkholderia mallei ∆tonB Mutant and its Potential as a Backbone Attenuated Strain for Vaccine Development
Mott, TiffanyIn this study, a Burkholderia mallei ∆tonB mutant deficient in iron acquisition was constructed, characterized and evaluated for its protective properties in acute inhalational mouse models of glanders and melioidosis ... -
Construction, characterization, and evaluation of CLH001 as a vaccine candidate against respiratory glanders
Hatcher, Christopher Lawrence; 0000-0003-2637-3035Burkholderia mallei is the causative agent of glanders, an incapacitating disease with high mortality rates in respiratory cases. Its endemicity and ineffectual treatment options emphasize its public health threat and ... -
Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
Calderon, Veronica ElenaMycobacterium tuberculosis (M.tb) is the most common co-infection and leading cause of death among HIV+ individuals. Several animal models are available to study TB infection although many do not reproduce disease pathology ... -
Discovery and characterization of a newly emerged DENV serotype.
Mayer, Sandra V.; 0000-0002-5767-8870Dengue virus (DENV) is a mosquito-transmitted flavivirus that presents a substantial threat to public health worldwide. One third of the global population is at risk of infection and over 400 million cases of dengue are ... -
Identification of protective rickettsial antigens for vaccine development
Caro-Gomez, ErikaThe genus Rickettsia contains some of the most lethal pathogens known to man, including Rickettsia prowazekii, a select agent that could be used as a biological weapon. Although Rickettsia spp. cause important diseases ... -
Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
Jie, ZuliangIntrahepatic cell-derived IL-17 and IL-22 are important for T cell priming and hepatoprotection in viral hepatitis, respectively; however, the source and regulation of these cytokines in the liver microenvironment are not ... -
Modeling host responses to tick feeding and tick-borne flavivirus evolution and dispersal
Heinze, DarIxodid ticks are hematophagous arthropods that feed on host animals for an extended period of time. To facilitate feeding, ticks secrete a complex mixture of salivary molecules that inhibit host responses such as coagulation, ... -
Neutrophil interactions with Leishmania amastigotes: implications for chronic leishmaniasis
Carlsen, Eric DonaldLeishmaniasis is a neglected tropical disease responsible for considerable morbidity and mortality in the developing world. The immune response against Leishmania parasites must be fine-tuned to promote pathogen clearance ... -
Pathology and mechanisms of increased M.tb growth and dissemination during co-infection with HIV-1
Nusbaum, Rebecca Jordan; 0000-0002-8378-8037Around one third of the world’s population is latently infected with Mycobacterium tuberculosis (M.tb). M.tb and HIV have a deadly synergy that occurs during co-infection. Individuals with HIV infection are at significantly ... -
Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
Chesson, Charles Brent; 0000-0001-9668-8863CD8+ T cells play a central role in immunity against intracellular pathogens and cancer.Vaccines that elicit robust CD8+ T cell responses are desirable for protection against such infectious diseases and cancers. Subunit ... -
The invasin IbeA and its role in Adherent-Invasive Escherichia coli (AIEC) pathogenesis
Cieza, Roberto Javier; 0000-0001-7400-722XIn this study, an Adherent-Invasive Escherichia coli (AIEC) ∆ibeA mutant was constructed and characterized, and its effect on AIEC adhesion and invasion of intestinal epithelial cells evaluated. The role that this outer ...