Browsing by Department "Experimental Pathology"
Now showing items 1-20 of 64
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Adaptation of Chikungunya virus to Aedes albopictus mosquitoes: The role of mutations in the E1 AND E2 glycoproteins
(2009-10-08)Chikungunya virus (CHIKV) is a positive sense single-stranded RNA virus in the family Togaviridae that between 2005 and 2007 caused its largest outbreak/epidemic in documented history, affecting parts of Africa, the Indian ... -
Airway Inflammatory States in Response to Environmental Pollutants and the Influence of Oxidative Balance
Asthma continues to grow as a major health issue worldwide. Epidemiologic evidence points to a link between urban air pollution and exacerbation of asthma cases. The pathophysiology of airway inflammation and hyperresponsiveness ... -
ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
Sequelae are defined as a condition resultant of disease, typically a chronic complication of an acute illness. Neurological sequelae are those complications involving the brain and central nervous system and can include ... -
Arenavirus Attenuation Mechanisms
Arenaviridae derives from the Latin word ‘arena’ meaning ‘sand’. When scientists first looked at arenavirus virions by transmission electron microscopy, they saw pleomorphic particles that had a sandy appearance. This sandy ... -
Autophagy and Inflammation During Rickettsial Infection
Rickettsiae are obligately intracellular bacteria that replicate in the cytoplasm of host cells. In my dissertation, I have studied the induction of autophagy by rickettsiae as well as the role of autophagy in the ... -
Bacterial and host dynamics of Mycoplasma genitalium infection of the human female reporductive tract
(2009-03-02)Mycoplasma genitalium (MG) is an emerging sexually transmitted pathogen that is associated with several inflammatory syndromes including cervicitis and pelvic inflammatory disease. Despite the clinical associations of MG ... -
Biological studies of GPI-anchoring in Trypanosoma cruzi
(2007-04-24)Trypanosoma cruzi, a protozoan parasite transmitted to humans via triatomine\r\ninsects, causes chronic chagasic cardiomyopathy (CCM) in ~30% of infected individuals.\r\nThis dissertation sought to characterize T. cruzi’s ... -
Carbon Catabolite Regulation of Yersinia pestis Pathogenesis
In order to survive in the unique environments associated with different aspects of the infectious cycle, Yersinia pestis evokes adaptive responses to concertedly regulate gene expression. The overall objective of this ... -
Characterization of a Newly Identified Alphavirus, Eilat Virus
Most alphaviruses are mosquito-borne and exhibit a broad host range, infecting many different vertebrates including birds, rodents, equids, humans, and nonhuman primates as well as mosquito species encompassing at least ... -
Characterization of a recombinant chimeric yellow fever 17D vaccine - dengue-4 virus
The disease dengue is caused by four genetically and serologically related virus termed dengue virus-1 to dengue virus-4 (DENV-1 to DENV-4) There are currently no licensed therapeutics, but there is a recently licensed ... -
Characterization of genetic reassortment and recombination potentials between Arumowot Virus and MP-12 vaccine strain
Rift Valley fever virus (RVFV) is a zoonotic arbovirus that causes significant morbidity and mortality in both humans and animals. In humans, the disease manifests itself as febrile illness, hemorrhagic fever, encephalitis, ... -
Characterization of the molecular and biological determinants of viral dissemination from the mosquito midgut: Yellow feber virus in Aedes aegypti
(2006-08-15)In order for a mosquito-borne virus to be transmitted from an infected mosquito to a vertebrate host, virus must disseminate from the mosquito midgut- the initial site of infection following uptake of an infectious bloodmeal- ... -
Characterization of the role of the innate immune system in the pathogenesis of chikungunya virus in mice
Chikungunya virus (CHIKV) is an alphavirus which causes a febrile illness in people that can induce a persistent and recurrent arthralgia. Recent outbreaks of CHIKV in tropical regions have caused millions of people ... -
Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
(2005-07-12)Guinea pig infection with the arenavirus Pichinde provides an animal model for human Lassa fever, a disease that affects 300,000 to 500,000 people a year in western Africa. Low passage Pichinde virus (P2) induces a mild ... -
Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
Mycobacterium tuberculosis (M.tb) is the most common co-infection and leading cause of death among HIV+ individuals. Several animal models are available to study TB infection although many do not reproduce disease pathology ... -
Development of a Murine Model of Severe Scrub Typhus And Its Use to Elucidate the Immune Response to and The Pathology that Occurs during Orientia Tsutsugamushi Infection.
Scrub typhus is an often lethal infection that threatens one billion persons globally and causes illness in one million people annually. There is no vaccine for scrub typhus, and the mechanisms of protective immunity are ... -
Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response
Ehrlichia chaffeensis is an obligately intracellular bacterium that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies including modulation of host gene transcription. In ... -
Ehrlichia chaffeensis Type 1 Secreted Effector TRP47 is a Novel SUMOylated Nucleomodulin
Ehrlichia chaffeensis secretes immunodominant and immunoprotective protein effectors into the host cell using a type I secretion system. The best-characterized of these effectors are the tandem repeat proteins (TRPs). In ... -
Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
(2007-09-14)The clinical manifestations of HME caused by Ehrlichia chaffeensis, a Gram-negative, LPS-lacking bacterium, including toxic shock-like syndrome and liver injury in the absence of overwhelming bacterial burdens, has led to ... -
Elucidation of Mechanisms of Host Immunity against Orientia tsutsugamushi in a Newly Developed Murine Model
Scrub typhus, caused by a Gram-negative obligately intracellular coccobacillus, Orientia tsutsugamushi, is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each ...