Browsing by Department "Experimental Pathology"
Now showing items 1-20 of 48
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Adaptation of Chikungunya virus to Aedes albopictus mosquitoes: The role of mutations in the E1 AND E2 glycoproteins
(2009-10-08)Chikungunya virus (CHIKV) is a positive sense single-stranded RNA virus in the family Togaviridae that between 2005 and 2007 caused its largest outbreak/epidemic in documented history, affecting parts of Africa, the Indian ... -
Airway Inflammatory States in Response to Environmental Pollutants and the Influence of Oxidative Balance
Asthma continues to grow as a major health issue worldwide. Epidemiologic evidence points to a link between urban air pollution and exacerbation of asthma cases. The pathophysiology of airway inflammation and hyperresponsiveness ... -
Arenavirus Attenuation Mechanisms
Arenaviridae derives from the Latin word ‘arena’ meaning ‘sand’. When scientists first looked at arenavirus virions by transmission electron microscopy, they saw pleomorphic particles that had a sandy appearance. This sandy ... -
Bacterial and host dynamics of Mycoplasma genitalium infection of the human female reporductive tract
(2009-03-02)Mycoplasma genitalium (MG) is an emerging sexually transmitted pathogen that is associated with several inflammatory syndromes including cervicitis and pelvic inflammatory disease. Despite the clinical associations of MG ... -
Biological studies of GPI-anchoring in Trypanosoma cruzi
(2007-04-24)Trypanosoma cruzi, a protozoan parasite transmitted to humans via triatomine\r\ninsects, causes chronic chagasic cardiomyopathy (CCM) in ~30% of infected individuals.\r\nThis dissertation sought to characterize T. cruzi’s ... -
Carbon Catabolite Regulation of Yersinia pestis Pathogenesis
In order to survive in the unique environments associated with different aspects of the infectious cycle, Yersinia pestis evokes adaptive responses to concertedly regulate gene expression. The overall objective of this ... -
Characterization of the molecular and biological determinants of viral dissemination from the mosquito midgut: Yellow feber virus in Aedes aegypti
(2006-08-15)In order for a mosquito-borne virus to be transmitted from an infected mosquito to a vertebrate host, virus must disseminate from the mosquito midgut- the initial site of infection following uptake of an infectious bloodmeal- ... -
Characterization of the role of the innate immune system in the pathogenesis of chikungunya virus in mice
Chikungunya virus (CHIKV) is an alphavirus which causes a febrile illness in people that can induce a persistent and recurrent arthralgia. Recent outbreaks of CHIKV in tropical regions have caused millions of people ... -
Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
(2005-07-12)Guinea pig infection with the arenavirus Pichinde provides an animal model for human Lassa fever, a disease that affects 300,000 to 500,000 people a year in western Africa. Low passage Pichinde virus (P2) induces a mild ... -
Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
Mycobacterium tuberculosis (M.tb) is the most common co-infection and leading cause of death among HIV+ individuals. Several animal models are available to study TB infection although many do not reproduce disease pathology ... -
Development of a Murine Model of Severe Scrub Typhus And Its Use to Elucidate the Immune Response to and The Pathology that Occurs during Orientia Tsutsugamushi Infection.
Scrub typhus is an often lethal infection that threatens one billion persons globally and causes illness in one million people annually. There is no vaccine for scrub typhus, and the mechanisms of protective immunity are ... -
Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
(2007-09-14)The clinical manifestations of HME caused by Ehrlichia chaffeensis, a Gram-negative, LPS-lacking bacterium, including toxic shock-like syndrome and liver injury in the absence of overwhelming bacterial burdens, has led to ... -
Evaluation of arthropod-borne virus recombination potential and phenotype: In vitro and in vivo analysis of flavivirus and alphavirus model systems
(2010-05-24)Recombination is a mechanism whereby positive sense single stranded RNA viruses exchange segments of genetic information. Recent phylogenetic analyses of naturally occurring recombinant flaviviruses have raised concerns ... -
Evaluation of Chikungunya Virus Infectious Events in Aedes Albopictus LR and Aedes Aegypti WE Mosquito Vectors
Arthropod-borne pathogens cause millions of human infections which are initiated by the feeding by an infected mosquito on a vertebrate, the interactions between the viruses and the mosquito vector that facilitate successful ... -
Experimental studies of the ecology and evolution of eastern equine encephalitis virus and implications for its emergence and classification
(2010-06-25)Eastern equine encephalitis virus strains from North (NA EEEV) and Central/South America (SA EEEV) have developed markedly different epidemiologic, pathogenic, antigenic, and genetic profiles, have distinct geographic ... -
Field and laboratory studies of venezuelan equine encephalitis virus ecology in Chiapas, Mexico.
(2009-03-05)The emergence of Venezuelan equine encephalitis virus in Chiapas Mexico was examined from a field approach and from a laboratory approach. This virus was not previously associated with equine disease in Mexico. The evolution ... -
Genetic Determinants of Junin Virus Attenuation
The New World arenavirus Junin (JUNV) is the causative agent of the Argentine hemorrhagic fever (AHF), a deadly disease endemic to central regions of Argentina. The live-attenuated Candid #1 strain of JUNV is currently ... -
Genotypic and Phenotypic Determinants of Japanese Encephalitis Virus Geographical Expansion
Japanese encephalitis virus (JEV) consists of at least four geographically and epidemiologically distinct genotypes (GI-IV). Genotypes II and IV have been isolated in tropical Asia only, and GI has recently replaced GIII ... -
Host-Dependent Expression, Transcriptional Regulation and Protection of Ehrlichia chaffeensis Tandem Repeat Proteins
Ehrlichia chaffeensis is an obligately intracellular bacterium that is the causative agent of human monocytotropic ehrlichiosis, an emerging life-threatening zoonosis. E. chaffeensis is transmitted by the lone star tick, ... -
Identification and characterization of cell-adapted mutations in West Nile Virus and replicons
(2007-12-19)Flavivirus persistence in cell culture is achieved by altering the interaction between the viral genome and the host cell. To identify some of the factors that contribute to a persistent West Nile virus (WNV) infection, ...