Browsing Electronic Theses and Dissertations by Department "Pharmacology and Toxicology"
Now showing items 1-20 of 40
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Buprenorphine metabolism by preterm placentas: A pilot study
(2007-10-31)The focus of this investigation is to attempt to identify and characterize the major enzyme responsible for metabolism of buprenorphine to nor-buprenorphine in human preterm placentas and to elucidate whether the ... -
CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
Over the past decade, growing evidence indicates that adult neurogenesis (the production of functionally mature neurons from progenitor cells in the adult mammalian brain) is linked to the etiology of many neurodegenerative ... -
Cellular mechanisms that modulate kainate receptor trafficking and assembly
(2007-06-08)Kainate receptors (KARs) in the mammalian brain play a variety of physiological roles that require selective assembly, intracellular trafficking, and synaptic targeting. Cytoplasmic and non-cytoplasmic determinants that ... -
Characterization of serum-induced CYP1A1 expression and activity in mouse embryo fibroblasts
(2005-07-07)The AhR is a ligand-activated transcription factor that mediates the toxic effects of environmental contaminants that include TCDD. Using a TCDD dose-response treatment in MEFs, we observed a super induction of CYP1A1 with ... -
Chemical Mixtures of Xenoestrogens and Their Metabolites Alter Estradiol-Induced Non-Genomic Signaling
(2013-06-03)BACKGROUND: Xenoestrogens (XEs) pose a threat to human health by disrupting natural responses of physiologic estrogens. Bisphenol-A (BPA), a plastics monomer, is potently estrogenic via non-genomic signaling; however, ... -
Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
A decreased signaling capacity at the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) regulates neurobehavioral processes that may underlie chronic health issues such as impulsivity disorders, drug addiction, depression, ... -
“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
(2005-07-08)Parathyroid hormone-related protein (PTHrP) is expressed by prostate cancer cells. Since PTHrP enhances the growth and osteolytic potential of prostate cancer cells, it is important to control PTHrP expression in these ... -
DISRUPTION OF THE HIPPOCAMPAL GABAERGIC SYSTEM IN THE Fgf14 ̶ / ̶ MOUSE MODEL
In CNS, cognitive function is greatly dependent on the functional integrity of gamma-amino-butyric acid (GABA) interneurons. These inhibitory interneurons modulate synaptic plasticity and intrinsic excitability of principal ... -
Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference
(2008-11-24)One of the biggest problems facing cocaine addicts is relapse and currently there are no treatments for relapse. These studies will provide insight into the underlying mechanisms of LTP mediating relapse to cocaine. A ... -
Effects of perinatal phencyclidine treatment on neuronal viability, N-methyl-D-aspartate receptor regulation and schizophrenic-like behaviors
(2009-03-06)Clinical use of phencyclidine (PCP), a potent dissociative anesthetic, was abandoned as a result of reports of post-operative hallucinations and disoriented behavior; further, illicit use has substantially diminished because ... -
EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
The recent discovery of a new family of cAMP sensor proteins, exchange protein activated by cAMP (EPAC), ushered in a new era in cAMP signaling. EPAC is composed of two main isoforms, EPAC1 and EPAC2, whose roles in mediating ... -
Folate Receptor-Targeted Transplacental Delivery of Digoxin for the Treatment of Fetal Arrhythmia
Fetal tachyarrhythmias is one of the leading causes of fetal hydrops and, ultimately, fetal demise. This condition is typically treated with transplacental digoxin by maternal administration. However, maternal digoxin ... -
A general scaffold for the synthesis of cysiherbaine and its analogues
(2008-12-03)Dysiherbaine 1 and a select number of structurally related compounds have been shown to have selective effects on ionotropic glutamate receptors (iGluRs). iGluRs are essential components in the central nervous system (CNS); ... -
Methadone metabolism in placentas from preterm pregnancies
(2005-07-20)The aim of this investigation is to identify and characterize the enzyme system responsible for the N-demethylation of methadone in human preterm placentas. The metabolism of methadone revealed typical Michaelis-Menten ... -
Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
(2013-06-03)The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, attenuates liver regeneration in vivo when activated by its prototypical agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) following 70% partial ... -
Novel Insights Into Normal Aryl Hydrocarbon Receptor Biology Through the Regulation of Stanniocalcin 2
(2013-06-03)Proper hepatocyte function is vital for survival; hence unrepaired destruction of the parenchymal tissue leading to liver decompensation is devastating. Therefore, understanding the homeostatic process regulating liver ... -
Paclitaxel nanoparticles for breast cancer therapy in pregnancy
Breast cancer can complicate pregnancy and result in fetal and maternal morbidity and mortality. These effects are often compounded by restrictions in the diagnosis and treatment of breast cancer due to implications on ... -
Pharmacokinetics of Bupropion and its Pharmacologically Active Metabolites in Pregnancy
Bupropion, an antidepressant and anti-smoking medication, is used for treatment of depression during pregnancy, however its efficacy as a smoking cessation aid in pregnancy has not been confirmed. The drug is extensively ... -
Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development
(2005-07-06)Disruptions in glutamatergic neurotransmission may play a role in the pathogenesis of schizophrenia. The purpose of this study was to determine phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition ... -
The role of 4-hydroxynonenal in cellular signaling mechanisms
(2007-04-03)One of the critical steps involved in cellular oxidative stress is the peroxidation of membrane lipids. The downstream effects of the autocatalytic lipid peroxidation (LPO) cycle are widespread and involve several processes. ...