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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
The intestine, a dwelling place for trillions of commensal bacteria, is constantly exposed to numerous ligands and antigens from foods and microbiota. Intestinal homeostasis involves a balance between anti-inflammatory and ...
The Role of UNC-45 in Heart Development and Human Breast Cancer
The C. elegans UNC-45 has been demonstrated as a molecular chaperone of body-wall muscle myosins. In human and other vertebrates, two UNC-45 genes code two UNC-45 protein isoforms: UNC-45A/a and UNC-45B/b. UNC-45A/a is ...
Inpatient Rehabilitation Outcomes for Patients with Debility
(2013-06-03)
Background: Inpatient rehabilitation facility (IRF) goals are to optimize functional independence and discharge patients to community living. Debility, or deconditioning associated with hospitalization, is the fourth ...
Post Traumatic Story Disorder: The Power of Story Telling and Story Hearing to Heal the Invisible Wounds of War
Beyond the visible physical wounds they suffer, soldiers traumatized by war often experience the debilitating effects of what psychiatrist Jonathan Shay calls moral injury and shrinkage of the social and moral horizon. ...
Relative Contributions of Complications and Failure to Rescue on Mortality in Older Patients Undergoing Pancreatectomy
OBJECTIVE AND SUMMARY BACKGROUND DATA: For pancreatectomy patients, mortality increases with increasing age. Our study evaluated the relative contribution of overall postoperative complications and failure to rescue rates ...
Relative Contributions of Complications and Failure to Rescue on Mortality in Older Patients Undergoing Pancreatectomy
OBJECTIVE AND SUMMARY BACKGROUND DATA: For pancreatectomy patients, mortality increases with increasing age. Our study evaluated the relative contribution of overall postoperative complications and failure to rescue rates ...
Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response
Ehrlichia chaffeensis is an obligately intracellular bacterium that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies including modulation of host gene transcription. In ...