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Impact of West Nile Virus Envelope Domain III Surface Loop Residues on Antigenicity and Virulence
West Nile virus (WNV) is an encephalitic flavivirus that is maintained worldwide in a transmission cycle between birds and mosquitoes. Domain III of its envelope protein is the target of highly specific and potently ...
Characterization of single-cycle flavivirus particles for use as a vaccine to prevent West Nile disease and to examine immune responses to flavivirus infection
(2009-08-28)
West Nile virus (WNV) is responsible for the largest outbreak of viral encephalitis in the history of North America, yet there are no vaccines available to prevent this disease. To address these needs we have developed ...
West Nile virus versus the host cell: Identification of host factors that modulate infection
(2008-08-27)
There are two competing aspects of virus-host interactions: (i) those that enhance virus transmission and (ii) those that reduce or prevent viral replication and transmission. Each of these types of interactions is critical ...
The Molecular Epidemiology of West Nile Virus in North America
West Nile virus (WNV) was introduced into North America in 1999. The original genotype of WNV in North America, NY99, was displaced in 2002 with the current dominant genotype, NA/WN02, which was first identified in 2002. ...
Identification and characterization of cell-adapted mutations in West Nile Virus and replicons
(2007-12-19)
Flavivirus persistence in cell culture is achieved by altering the interaction between the viral genome and the host cell. To identify some of the factors that contribute to a persistent West Nile virus (WNV) infection, ...
Epidemiology and clinical investigation of West Nile Virus encephalitis in Houston, Texas
(2006-08-17)
In 2002, West Nile virus (WNV) appeared in Houston. Retrospective medical chart reviews were completed for 172 WNV cases hospitalized in the Houston area between 2002 and 2004; 113 had encephalitis (including 17 fatal ...
Development of a Mouse Model of NY99 West Nile Virus-Induced Neurological Changes
West Nile virus is a mosquito-borne flavivirus with worldwide distribution that can cause severe neurological disease in those infected. After recovery, as many as 60% of patients report neurological deficits that can ...
Genotypic and Molecular Determinants in the Continued Evolution of West Nile Virus in the United States
Following the introduction of West Nile virus (WNV) into New York in 1999, the virus continues to evolve in the U.S. with the emergence, extinction, and co-circulation of multiple, distinct U.S. genotypes. Despite annual ...