West Nile virus (WNV) is a mosquito-borne flavivirus that causes neurological disease and fatalities annually in the United States and Europe, but no human WNV vaccines have been licensed. Studies of WNV vaccine candidates ...

In 2002, West Nile virus (WNV) appeared in Houston. Retrospective medical chart reviews were completed for 172 WNV cases hospitalized in the Houston area between 2002 and 2004; 113 had encephalitis (including 17 fatal ...

West Nile virus (WNV) is responsible for the largest outbreak of viral encephalitis in the history of North America, yet there are no vaccines available to prevent this disease. To address these needs we have developed ...

Flavivirus persistence in cell culture is achieved by altering the interaction between the viral genome and the host cell. To identify some of the factors that contribute to a persistent West Nile virus (WNV) infection, ...

Following the introduction of West Nile virus (WNV) into New York in 1999, the virus continues to evolve in the U.S. with the emergence, extinction, and co-circulation of multiple, distinct U.S. genotypes. Despite annual ...

There are two competing aspects of virus-host interactions: (i) those that enhance virus transmission and (ii) those that reduce or prevent viral replication and transmission. Each of these types of interactions is critical ...

West Nile virus is a mosquito-borne flavivirus with worldwide distribution that can cause severe neurological disease in those infected. After recovery, as many as 60% of patients report neurological deficits that can ...

West Nile virus (WNV) was introduced into North America in 1999. The original genotype of WNV in North America, NY99, was displaced in 2002 with the current dominant genotype, NA/WN02, which was first identified in 2002. ...

West Nile virus (WNV) is an encephalitic flavivirus that is maintained worldwide in a transmission cycle between birds and mosquitoes. Domain III of its envelope protein is the target of highly specific and potently ...