Aging is associated with a slow, progressive loss of muscle mass and strength. Mechanical unloading, such as that commonly experienced during hospitalization or spaceflight, results in a rapid loss of muscle mass and ...

Research indicates that the health of the older population in the United States, as measured by most dimensions, has improved over the past two decades. Population-level changes in health have been attributed to increases ...

The purpose of this study was to investigate the functional status of a sample of older adults during hospitalization for acute illness and to examine associations between functional status measures assessed during ...

The Free Radical Theory of Aging states that there is an increase in reactive oxygen species (ROS) production with aging leading to increase in tissue dysfunction. Mitochondria are the major source of ROS, which damages ...

Aging and age-associated diseases have been associated with altered cellular signaling, chromatin perturbation, oxidative stress, and DNA damage, especially at the telomere. Despite having evolved a sophisticated surveillance ...

Background and Purpose: Arthritis is a major cause of disability with a sizable impact on health-related quality of life (HRQoL) in older adults, especially among older non-Hispanic white subjects. The purpose of this study ...

OBJECTIVES: This study describes cross-sectional and longitudinal racial/ethnic differences in cognitive function scores (memory and mental status), and the mediating roles of education and physical activity in late middle ...

It has been suggested that the gradual loss of muscle mass observed with healthy aging is the result of a resistance of aged muscle tissue to normally potent anabolic stimuli. Recent evidence indicates an age-related ...

Aging and skeletal muscle ischemia/reperfusion (I/R) injury both lead to skeletal\r\nmuscle dysfunction, evidenced by decreased contractile force generation, particularly in\r\nglycolytic muscle. The deficits in I/R are ...

Each year, more than 300,000 people fracture their hip. The number of hip fractures in the US is expected to increase with the aging of the population in the coming years; by 2040, 500,000 patients annually will sustain ...