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Genetic determinants of NEIL2 transcription
The human genome is constantly damaged by reactive oxygen species (ROS) which produce a multitude of oxidative DNA lesions that can lead to mutations, genomic instability, and ultimately, to the development of cancer and ...
Replication-associated base excision repair Of oxidized bases in the mammalian genome
Reactive oxygen species (ROS), the most pervasive endogenous and radiation-induced genotoxic agents induce strand breaks and a plethora of base lesions in DNA that (except double-strand breaks) are repaired via the DNA ...
Characterization of the DNA repair role of the Saccharomyces cerevisiae NSE1 gene
In eukaryotes, the structural maintenance of chromosomes (SMC) complexes play important roles in chromosome dynamics. The Saccharomyces cerevisiae Smc5-Smc6 complex is composed of eight essential subunits and is particularly ...
Biological and functional consequences of polymorphisms in the XPD gene
Epidemiological studies have documented many associations between single nucleotide polymorphisms (SNPs) in the nucleotide excision repair gene XPD (ERCC2) and cancer risk. Little is known, however, about the underlying ...