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Signaling crosstalk in cancers
Deregulation of cellular signaling contributes to the malignant phenotype of cancer. In this dissertation, cross-talk among oncogenic signaling pathways was investigated in two common human cancers. \r\n Pancreatic cancer ...
Engineering functionalized gold nanoparticles as a molecular-specific contrast agent to enhance optoacoustic detection of breast cancer cells
Molecular targeting of malignant tumors is a promising field of research that could potentially revolutionize the diagnosis and treatment of many types of cancer including breast. Delivering molecular specific contrast ...
A mechanism of activation of c-MET receptor tyrosine kinase
c-MET receptor tyrosine kinase-mediated signaling governs numerous important cellular responses including cellular proliferation, differentiation, migration and apoptosis. Deregulation of these signals result in malignant ...
Biological and functional consequences of polymorphisms in the XPD gene
Epidemiological studies have documented many associations between single nucleotide polymorphisms (SNPs) in the nucleotide excision repair gene XPD (ERCC2) and cancer risk. Little is known, however, about the underlying ...