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Use of surface enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF MS) to study protein expression in a rat model of cocaine withdrawal
(2005-07-22)
SELDI-TOF MS is an analytical technology that combines chromatography and mass spectrometry. It is being exploited for the measurement of numerous proteins in serum, less often in organ tissue (rarely in brain). We applied ...
UTMB's History of Care for the Indigent
(2008-02-24)
Today, 24.1 percent of Texas inhabitants have no health insurance, by choice or happenstance; medical inflation is approximately 6 percent annually; and federal support for indigent health care is eroding in the face of a ...
The essence of the experience of polypharmacy in the life-world of the community dwelling elder
(2008-02-29)
Thirteen percent of the United States’ population is 65 years of age and older, and\r\nconsumes 33% of prescribed medications and 40% of over the counter medications. Most\r\nresearch addressing polypharmacy in the elderly ...
Regulation of BACE1 promoter activity by nuclear factor-kappaB\r\n
(2005-06-30)
The brains of Alzheimer’s disease (AD) patients display cerebrovascular and parenchymal deposits of beta-amyloid peptides, which are derived by proteolytic processing of the amyloid precursor protein (APP). The beta-site ...
Identificaiton of the pore-lining helices of connexin 43 gap-junctional hemichannels
(2008-03-28)
The gap-junctional channels that mediate intercellular communication are formed by head-to-head docking of two gap-junctional hemichannels from adjacent cells. The hemichannels are hexamers of connexins, proteins that have ...
Functional genomic analysis of PPAR-gamma in human colorectal cancer cells
(2006-12-14)
The gamma isoform of peroxisome-proliferator activated receptor (PPAR-gamma) is a member of the super family of nuclear hormone receptors and shows much promise as a chemopreventative and therapeutic target for colorectal ...
Characterization of the effects of Interferon gamma protein-10 (CXCL10) against the protozoan parasite Leishmania amazonesis
(2007-06-26)
Leishmania amazonensis causes progressive disease in most inbred strains of mice. We have previously shown that L. amazonensis-infected C57BL/6 mice have profound impairments in expression of pro-inflammatory cytokines, ...
Cytokine patterns in a comparative model of arenavirus infection: Implications for virulence and control of viral replication
(2005-07-12)
Guinea pig infection with the arenavirus Pichinde provides an animal model for human Lassa fever, a disease that affects 300,000 to 500,000 people a year in western Africa. Low passage Pichinde virus (P2) induces a mild ...
Arthritis impact on the physical function, disability, and health-related quality of life among older Mexican-Americans
(2009-03-02)
Background and Purpose: Arthritis is a major cause of disability with a sizable impact on health-related quality of life (HRQoL) in older adults, especially among older non-Hispanic white subjects. The purpose of this study ...
The lived experiences of prenatal stress and mind-body exercises: Reflections of post-partum women
(2009-03-13)
Prenatal stress experienced by pregnant women has been linked to risky and unfavorable birth outcomes. The majority of quantitative research reports found in the literature consistently make the point that elevated prenatal ...