Now showing items 1-6 of 6
Bax-mediated coordination of cognate organelle cell death signaling cascades determines cell death phenotype after trauma in the neonatal rat cortex
Bax translocation to the mitochondria has been well-characterized to induce apoptotic cell death in multiple injury paradigms. However, pro-cell death actions for Bax outside of the mitochondria remain understudied. Bax’s ...
Mechanisms of imporvement following functional inhibition of nitrosative stress after brun and smoke-induced acute lung injury
Severe trauma, caused by flame burn and smoke (B + S) inhalation induces acute lung injury (ALI) and results in the loss of pulmonary function. A cascade of molecular and cellular events initiates the formation of reactive ...
Mechanisms of increased microvascular permeability during acute Rickettsiosis
Rickettsial diseases represent some of the most severe bacterial infections in man including Rocky Mountain spotted fever and epidemic typhus. Rickettsiae primarily target the microvascular endothelium leading to increased ...
A Missing link between lipid metabolism, inflammation and apoptosis: Phospholipase A2-activating protein (PLAA)
Phospholipase A2-Activating Protein (PLAA) is a novel signaling molecule that regulates the production of arachidonic acid (AA), prostaglandin E2 (PGE2) and TNF-¦Á. Literature suggests that PLAA could be involved in ...
Mechanisms of improvement following functional inhibition of neutrophil infiltration after spinal cord injury
Spinal Cord Injury (SCI) is a traumatic event that results in loss of function below the level of injury, and other dysfunctions including pain syndromes, both above and below the level of the lesion. A cascade of biochemical ...
The role of reactive oxygen species as mediators of respiratory syncytial virus induced pulmonary inflammation
Respiratory Syncytial Virus (RSV) is the leading cause of epidemic respiratory tract illness in children worldwide. Although the mechanisms of RSV-induced airway disease are unknown, experimental evidence suggests that ...