Increased cytokine levels have been observed in post mortem brains of Alzheimer Disease (AD) patients accompanied by a decrease in nerve growth factor (NGF)-responsive cholinergic neurons. I report a synergistic effect ...

A major yet unsolved quest in treating traumatic brain injury (TBI) is the understanding of the secondary cellular injury that contributes to cell death. Whether zinc ions are toxic or protective in TBI is controversial. ...

The human genome is constantly damaged by reactive oxygen species (ROS) which produce a multitude of oxidative DNA lesions that can lead to mutations, genomic instability, and ultimately, to the development of cancer and ...

Amyotrophic lateral sclerosis (ALS) is an incurable neurological disease characterized by the selective degeneration of spinal and upper motor neurons. One approach in the development of therapies for ALS is to explore the ...

Neuropathic pain caused by peripheral nerve damage results in ectopic neuronal excitability, primary sensory neuron degeneration, loss of inhibition by spinal GABAergic neurons and more importantly, the development of ...

Reactive oxygen species (ROS), the most pervasive endogenous and radiation-induced genotoxic agents induce strand breaks and a plethora of base lesions in DNA that (except double-strand breaks) are repaired via the DNA ...

The Free Radical Theory of Aging states that there is an increase in reactive oxygen species (ROS) production with aging leading to increase in tissue dysfunction. Mitochondria are the major source of ROS, which damages ...

Apoptosis or programmed cell death is a highly regulated cellular process which is essential for the development of an organism as well as for tissue and organ maintenance. Dysregulation of apoptosis is responsible for a ...

Respiratory Syncytial Virus (RSV) is the leading cause of epidemic respiratory tract illness in children worldwide. Although the mechanisms of RSV-induced airway disease are unknown, experimental evidence suggests that ...