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Bax-mediated coordination of cognate organelle cell death signaling cascades determines cell death phenotype after trauma in the neonatal rat cortex
Bax translocation to the mitochondria has been well-characterized to induce apoptotic cell death in multiple injury paradigms. However, pro-cell death actions for Bax outside of the mitochondria remain understudied. Bax’s ...
Mechanisms of increased microvascular permeability during acute Rickettsiosis
Rickettsial diseases represent some of the most severe bacterial infections in man including Rocky Mountain spotted fever and epidemic typhus. Rickettsiae primarily target the microvascular endothelium leading to increased ...