Published ETD Collection
Recent Submissions
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Neuronal and Vascular Degeneration of the aging retina in the 3xTg-AD mouse
Alzheimer's disease (AD), a progressive and irreversible neurodegenerative disease and the most common cause of dementia in the United States, is characterized by amyloid β (Aβ) and tau deposition in the central nervous ... -
Medical Virtue in Contemporary Practice: Has COVID-19 Reawakened Virtue in the Modern Medical Encounter?
Crises like the COVID-19 pandemic further unsettle an already overburdened healthcare system, leading medical professionals to reevaluate priorities and redefine their professional identities. Focusing particularly on the ... -
Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
Burkholderia mallei (Bm) and B. pseudomallei (Bpm) are facultative intracellular pathogens and the causative agents of glanders and melioidosis. At present, effective vaccines for the prevention of glanders, or melioidosis ... -
The Role of Short-Chain Fatty Acids on Intestinal Epithelial Cell Migration
Inflammatory Bowel Disease (IBD) is a chronic remitting and relapsing autoimmune disorder of the gastrointestinal tract that affects millions of people worldwide with incidence and prevalence on the rise. Increases in the ... -
Characterization and therapeutic evaluation of a traumatic brain injury model in compliance with common data elements
Traumatic brain injury (TBI) is a major public health problem. It represents the leading cause of morbidity and mortality in children and young adults, resulting in long- term sequelae for a considerable number of survivors. ... -
Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
Neurogenesis, a physiological process by which new neurons are generated from neural stem cells (NSC), occurs throughout life, subverting the old dogma stating to the inability of the adult brain to replace neurons. In the ... -
The broken genome: Merging cutting edge technologies for a molecular understanding of the Flock House virus defective interfering particle.
Defective RNAs are natural versions of a viral genome that have been truncated or rearranged by non-homologous recombination. While not encoding for functional viruses, they can be amplified and co-passaged with the wild-type ... -
Longitudinal Visualization of Neurodegeneration: Digital Biopsy of the Retina
As treatment for most retinal diseases only begins after vision impairing degeneration is detectable, a better understanding of what changes lead to neurodegeneration is required. Due to the isolated physiology of the eye, ... -
The development and use of cutting edge next generation sequencing methodologies to study RNA viruses
With new next generation sequencing technologies and methodologies being published often, our ability to sequence viruses and host transcriptomes (in response to viral infection) has expanded – driving virology forward. ... -
Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
The innate immune system recognizes pathogens via unique signals present in the invading organism upon infection known as pathogen-associated molecular patterns (PAMPs). Recognition of PAMPs during viral infection requires ... -
Male-specific mechanisms in a murine model of nociplastic pain
In order to address how acute nociceptive pain can transition to nociplastic pain, we developed a murine model in which acute injury-induced mechanical hypersensitivity was prolonged beyond its normal resolution time ... -
Male-specific mechanisms in a murine model of nociplastic pain
In order to address how acute nociceptive pain can transition to nociplastic pain, we developed a murine model in which acute injury-induced mechanical hypersensitivity was prolonged beyond its normal resolution time ... -
Discovery and characterization of a newly emerged DENV serotype.
Dengue virus (DENV) is a mosquito-transmitted flavivirus that presents a substantial threat to public health worldwide. One third of the global population is at risk of infection and over 400 million cases of dengue are ... -
The Role of Presynaptic Par-1 Kinase in Regulating the Localization of Active Zone Protein BRP
Precise localization of synaptic proteins is required for proper synaptic function, which is compromised in many neurodevelopmental and neurodegenerative diseases. Since proteins that reside at the active zones are used ... -
Implementing an Undefined Job: A Classical Grounded Theory Study Exploring the Perceptions of Oncology Clinical Trial Nurses Encountering Ethical Challenges in Practice
The clinical trial nurse (CTN) has been recognized as a specialty nursing practice in which the nurse balances the care of a volunteer research participant with the requirements of a clinical trial; the oncology clinical ... -
Evaluating the Feasibility of a Nurse-driven Follow-up Telephone Triage Intervention to Improve Post-treatment Outcomes in Head and Neck Cancer Patients Undergoing Chemotherapy and Radiation in the Ambulatory Setting
Head and neck cancers (HNCs) account for 3% to 5% of all cancers in the United States. HNC remains a considerable challenge to both patients, families and family caregivers, and healthcare providers because of persistent ... -
Characterization of Candidate Mutations for Use in a Live Attenuated West Nile Virus Vaccine
West Nile virus (WNV) is a mosquito-borne flavivirus that causes neurological disease and fatalities annually in the United States and Europe, but no human WNV vaccines have been licensed. Studies of WNV vaccine candidates ... -
Investigation of Huntingtin’s Role in DNA Repair and Transcription
Huntington’s disease (HD) is a devastating and fatal neurodegenerative disease, caused by the expansion of a CAG repeat tract in the mutant Huntingtin gene (mHTT). The mechanism of toxicity imparted by mHTT has yet to be ... -
Investigating the mechanism of RNA packaging in Rift Valley Fever phlebovirus
Rift Valley fever phlebovirus (RVFV) is a trisegmented, single-stranded, negative-sense RNA genome, consisting of L, M and S segments. The virion carries two envelope glycoproteins, Gn and Gc, along with ribonucleoprotein ... -
Interrogation of the human glutamate dehydrogenase antenna to elucidate its role in allosteric regulation and disease
Glutamate dehydrogenase (GDH) catalyzes the reversible oxidative deamination of L-glutamate using NAD(P)+ as a coenzyme. GDH is found in all living organisms, but only GDH from animals is highly allosterically regulated ...
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