Published ETD Collection
Recent Submissions
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
In order to develop an effective vaccine for HSV-2 it is important to adequately understand the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available ... -
Manipulation of the Rift Valley Fever Virus M-Segment for Vaccine Development
Rift Valley fever virus (RVFV) is a phlebovirus of the virus family, Bunyaviridae. Since the early 1900s, RVFV has continually caused economically devastating outbreaks in livestock and severe disease in humans. In ... -
Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular Function, Histopathological and Behavioral Outcomes in Rats
(2018-05-22)Impact traumatic brain injury (i.e. non-blast TBI) is often associated with reduced cerebral perfusion and impaired cerebrovascular function due, in part, to the generation of reactive oxygen (ROS) and reactive nitrogen ... -
Does Context Matter to ACEs? The Role of State Economic Context and Selected State Policies in Childhood Adversity
Childhood adversity is a widespread public health problem in the United States. Half of adults experienced at least one serious adversity during childhood, and a quarter experienced two or more. Childhood adversity, often ... -
¡No Smoking Por Vapor! Systematic Literature Review Examining the Attitudes Toward, Beliefs About, Perceived Risks and Benefits of Electronic Cigarettes and Toward Their Use Among United States Youth
Electronic cigarettes are an emerging topic of discussion and debate in Public Health. Their ability to deliver nicotine in the form of vapor gave rise to the idea of electronic cigarettes being used as nicotine replacement ... -
Protein-Protein Interactions with Serotonin G Protein Coupled Receptors: Novel Targets for Neurotherapeutics Drug Discovery
G protein coupled receptors (GPCRs) are involved in many physiological processes and are important therapeutic targets for a variety of human health disorders. In fact, approximately 30% of current FDA-approved medications ... -
Upcoding in Medicare Population; Evolving frequencies of comorbidities among Medicare beneficiaries hospitalized for Chronic Obstructive Pulmonary Disease
Introduction: The economic impact of upcoding on health care system has been profound. Current data of how chronic obstructive pulmonary disease (COPD) patients’ comorbidities have evolved over time are lacking. Objective: ... -
Complexity of transcription factor target search: effect of DNA natural decoys and DNA methylation through interplay with methyl-CpG-binding proteins on transcription factor DNA association
Functions of transcription factors require formation of specific complexes at particular sites in cis-regulatory elements of genes. However, chromosomal DNA contains numerous sites that are similar to the target sequences ... -
First Aid Kit and Emergency Medical Kit Onboard Commercial Aircraft: A Comparative Study of American, European, Indian, Indonesian, Emirati, and Canadian Civil Aviation Regulations
There were 3.696 billion air passengers worldwide in the year 2016, and that number is expected to increase in the foreseeable future. As more passengers travel by air for both leisure and business, more in-flight medical ... -
COMPARING DIABETES SELF-CARE ACTIVITIES AND HEALTH PROMOTION LIFESTYLES AMONG SOUTH ASIAN WOMEN WITH NEW AND ESTABLISHED TYPE 2 DIABETES DIAGNOSES
Abstract The South Asian population is one of the fastest growing minority groups in the US, has a high prevalence of diabetes mellitus and the highest rate of cardiovascular disease in the world. Although men and women ... -
Neutrophil interactions with Leishmania amastigotes: implications for chronic leishmaniasis
Leishmaniasis is a neglected tropical disease responsible for considerable morbidity and mortality in the developing world. The immune response against Leishmania parasites must be fine-tuned to promote pathogen clearance ... -
Post traumatic story disorder: using the power of narrative to heal the invisible wounds of war
(2017-04-13)Abstract Soldiers traumatized by war often experience debilitating effects of invisible wounds such as post-traumatic stress disorder (PTSD). An obstacle to recovery from PTSD for male soldiers can be an inability to ... -
Characterization of Codon Optimized Wild Type TDP-43 Mediated Neurodegeneration in a Drosophila Model for ALS.
TAR DNA Binding Protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration-ubiquitin (FTLD-U). The exact mechanism by which TDP-43 ... -
The development of a reverse genetics system for Machupo virus
The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV), is a highly lethal viral pathogen with no approved vaccine or therapeutic to limit infection or outbreaks. Following implementation of rodent ... -
Elevated temperature alters cytokine output and c-Jun N-terminal kinase signaling downstream of toll-like receptor activation
Fever is a fundamental and important response to infection. Previous studies have shown that alterations in temperature can alter the phenotype of innate immune cells, such as phagocytic ability, but the effects of elevated ... -
Predictors of prolonged opioid use following lumbar fusion
The United States has the highest rate of lumbar fusion in the world.1 The lumbar fusion rate increased 2.4 times between 1998 and 2008.2 Rates of opioid pain reliever (OPR) use at 24 months post-lumbar fusion have been ... -
Modeling host responses to tick feeding and tick-borne flavivirus evolution and dispersal
Ixodid ticks are hematophagous arthropods that feed on host animals for an extended period of time. To facilitate feeding, ticks secrete a complex mixture of salivary molecules that inhibit host responses such as coagulation, ... -
PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model
Cognitive impairment is a quintessential feature of Alzheimer’s disease (AD) and AD mouse models. We and others have previously reported the peroxisome-proliferator activated receptor gamma (PPARγ) agonist rosiglitazone ...
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