Published ETD Collection
Recent Submissions
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Evaluating the Effect of Chronic Alcohol, Cocaine, and Co-Administration on Endogenous Adult Neural Stem Cell Survival, Differentiation, and Proliferation
Cocaine and alcohol are two of the most commonly co-abused substances, and the third most fatal drug combination. Efforts in drug addiction research primarily focus on preventing or stopping abuse; however little work is ... -
Chemokine CXCL7 Monomer, Homodimer, and Heterodimer: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
Platelet-derived chemokine CXCL7 (NAP-2) plays a critical role in mediating the crosstalk between platelets and neutrophils for initiating repair during vascular injury. CXCL7 function is coupled to CXCR2 receptor activation ... -
Dementia Risk in Elders with Anxiety and Insomnia
Current evidence suggests that there is an association between benzodiazepine-receptor-agonist medications (BZRA) and subsequent dementia. Expert opinions differ regarding whether the association indicates a causal ... -
Mechanisms of attenuation of the live Junin virus vaccine strain, Candid #1
Millions of individuals are at risk of arenavirus infection worldwide, with untreated infections often resulting in potentially lethal disease. Junin virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), ... -
PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
TP508 is a therapeutic peptide that represents a specific receptor-binding domain of human thrombin with many potential clinical applications. However, it shares several weaknesses common to peptides when administered ... -
Hypertension Screening of Commercial Divers from an Occupational Medicine Perspective
Hypertension is one of the most common chronic diseases in the world: in the US, it affects one third of the adult population. Most cases are primary hypertension - with no identified cause - and significantly increase the ... -
The Development of an Emergency Response Plan for Medical Contingencies during Commercial Spaceflight at the Houston Spaceport
Commercial spaceflight has grown increasingly prominent over the last decade. Yet despite the obvious successes, commercial spaceflight is still in its relative infancy, and mishaps in the industry may be enough to lose ... -
Control of Cardiac Hypertrophic Signaling by Inositol 1,4,5-Trisphosphate Receptors
Calcium plays an integral role to many cellular processes including contraction, energy metabolism, gene expression, and cell death. The inositol 1,4,5-trisphosphate receptor (IP3R) is a calcium channel expressed in cardiac ... -
“Effect of a meditation-based strategy on sleep quality and perceived stress of healthy older adults living in the community.”
The study assessed the comparative effectiveness of two nonpharmacological interventions, Mantram, a meditation-based strategy, and sleep techniques, to improve sleep in the healthy older adults living in the community. ... -
Fibroblasts: Key Cells in Inflammation and Fibrosis
Angiotensin II (Ang II) infusion into normolipidimic mice leads to the development of aortic dissections and abdominal aortic aneurysm (AAA). IL-6 is a pro-inflammatory cytokine that is secreted by fibroblasts and macrophages ... -
Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology
Alzheimer’s Disease (AD) is a multifactorial neurodegenerative dementia with no curative therapeutic options. One of the earliest impairments in AD triggering cognitive decline is the synaptic dysfunction induced by the ... -
Effects of Stress Coping Mechanisms on Telomere length: A literature review.
Studies of telomeres in humans are inconsistently related to exposure to stressors but strongly related to cell life cycle and cell senescence. Cell level stressors are related to reductions in telomere length as well as ... -
Using Altered Fidelity Viruses to Study Viral Attenuation and Population Genetics During Vertebrate Host Infection
The requirement of arthropod and vertebrate hosts for the host life cycle of an arbovirus constrains its evolution. For the viral population to survive in two hosts, the ability to produce genetic diversity within the ... -
Non-invasive Optoacoustic Monitoring of Neonatal Cerebral Venous Oxygen Saturation
Peripartum asphyxia is a common cause of cerebral hypoxia and when severe can lead to neuronal injury and hypoxic-ischemic encephalopathy (HIE) in the newborn. HIE has been reported up to 3/1000 live births with a high ... -
Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology
Endometrial adenocarcinoma and leiomyomas are prevalent disorders of the same organ. Endometrial cancer, the most prevalently diagnosed gynecological cancer, is associated with mutated PTEN tumor suppressor gene. The type ... -
Characterizing interactions between cAMP responsive element binding protein 1 and methyl-CpG-binding protein 2 as a potential transcriptional activation complex
Transcriptional activity is controlled by many types of DNA binding proteins. In addition to transcription factors that activate transcription by recruitment of RNA polymerase II, there are proteins like methyl-CpG-binding ... -
Biophysical Analyses of Intermolecular Ion-Pairs in Protein-DNA Complexes
For biological processes, one of the most fundamental interactions is the formation of the ion pair. In protein-DNA complexes, ion pairs form between basic side chains, such as lysine and arginine, and the phosphate backbone ... -
Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
In order to develop an effective vaccine for HSV-2 it is important to adequately understand the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available ... -
Development and Utilization of a Bioengineered 3D Human Lung Model to Study Pathogenesis of Lung Disease
There is a great need for research models that mimic human lung physiology and lung pathologies such as chronic lung diseases and respiratory infections. The morbidity and mortality associated with lung disease and ... -
Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
In order to develop an effective vaccine for HSV-2 it is important to adequately understand the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available ...
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