Published ETD Collection
Recent Submissions
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An Unruly Mélange in a Postcolonial State: The Cultural Politics of Short-Term Global Health Engagements in Dominican Republic Bateyes
In order to understand the implications of short-term global health engagements [STGHE] for ethnic-Haitian im/migrant sugar laborers and their families living in Dominican Republic bateyes, this ethnographic study uses a ... -
Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response
Ehrlichia chaffeensis is an obligately intracellular bacterium that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies including modulation of host gene transcription. In ... -
Characterization of genetic reassortment and recombination potentials between Arumowot Virus and MP-12 vaccine strain
Rift Valley fever virus (RVFV) is a zoonotic arbovirus that causes significant morbidity and mortality in both humans and animals. In humans, the disease manifests itself as febrile illness, hemorrhagic fever, encephalitis, ... -
Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications
Traumatic brain injury (TBI) is a risk factor for the later development of Alzheimer’s disease (AD), although the mechanisms contributing to this increased risk are unknown. Insulin resistance is an additional risk factor ... -
The Effects of Oral Contraceptive Use on Ligamentous Injury Incidence in Females: A Potential for Prevention
Female athletes have higher incidence of anterior cruciate ligament (ACL) injury compared to males among sports requiring lower limb agility such as soccer and basketball. Often blamed on sex differences in biomechanics ... -
The Role of Long Distance Movement and Genetic Adaptation on the Evolution of West Nile virus in the New World
West Nile virus (WNV) is an emerging arbovirus that is maintained in an epizooitic cycle involving birds and mosquitoes. After a long history of circulation in the Old World, WNV was introduced into the US and identified ... -
"No One Died Today:" A Naturalistic Inquiry into the Perceptions and Experiences of School Nurses Dealing with Adolescents who Self-Harm
There is an increased incidence of self harm among middle and high school age adolescents. The school nurse (SN) is in a position to recognize this behavior (Cooke & James, 2009), but little is known about the school nurse’s ... -
RADIOSENSITIZING EFFECTS OF THROMBIN PEPTIDE TP508 ON MEDULLOBLASTOMA CANCER STEM CELLS
Brain cancer is the second leading cause of cancer-related deaths in children in the United States, with medulloblastoma leading all pediatric cases. With intensive treatments, including surgery, radiation, and/or chemotherapy, ... -
Joint Models for Longitudinal Analysis and Competing Risks in Survival Analysis
In longitudinal studies involving assessing ordinal disease(s) outcome across multiple time points, ignoring the correlations between the development and transition of the disease status and any informative potential ... -
ANALYSIS OF ADULT NEUROGENESIS AND HIPPOCAMPUS-DEPENDENT MEMORY IN MOUSE MODELS FOR AGING, ALZHEIMER’S DISEASE AND CRANIAL IRRADIATION-INDUCED NEUROINFLAMMATION
Aging in the brain is a complex process that affects every living being differently. Age-associated memory decline can be mild; however, memory can deteriorate quickly with in patients with mild cognitive impairment or a ... -
Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
HIV-1 infection of the nervous system causes various neurologic diseases. Synaptic degeneration is a critical underlying neurological pathology. However, the mechanism by which HIV-1 causes synaptic degeneration is unclear. ... -
REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
Malaria killed an estimated of 437,000 people last year, most of them children. While there is a vaccine nearly licensed, it only induces limited and short-lived protection. A major problem in the development of an effective ... -
The Parallax of Personalized Medicine: A Critical, Socio-Medical Analysis of the Trajectory of Pharmacogenomics and Genome Wide Association Studies
While neoteric medical technologies in the United States are heralded as fundamental to medical progress, they may simultaneously work to facilitate the victimization of people who do not have access to that progress. For ... -
Defining Molecular Mechanism of Egress in Cryptosporidium
Recent studies have identified Cryptosporidium as a major contributor to childhood disease in endemic areas. Current interventions are not ideal where only few have demonstrated anti-cryptosporidial activity and are often ... -
The Impact of Comorbidities on the Incidence of Cognitive Impairment and Dementia among Elderly Patients with Diabetes Mellitus
The rapid growth of older adult segment is striking not only in the United States but worldwide. One of the most serious and potentially high burdens on caregiver and economy are cognitive decline and Dementia. Diabetes ... -
PhD
Alzheimer’s disease (AD) is one of over 18 different disorders known as tauopathies, characterized by the pathological aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous ... -
Novel drug and exercise therapies to restore metabolic function in children with severe burns
Severe burns encompassing over 30% of the total body surface area result in a pathophysiological stress response characterized by increased cardiac workload, elevated energy expenditure, altered muscle metabolism, a severe ... -
Petrogenic Polycyclic Aromatic Hydrocarbon Levels and Health of Gulf Coast Communities Following the Deepwater Horizon Oil Spill
The 2010 Deepwater Horizon oil spill was responsible for the release of over five million barrels of crude oil, containing petrogenic polycyclic aromatic hydrocarbons (PAHs), into the Gulf of Mexico. Few studies have ... -
Effect of Obesity on Outcomes following Total Hip/Total Knee Arthroplasty among Medicare Beneficiaries with Osteoarthritis
This study examined the effect of obesity on immediate rehabilitation outcomes including functional performance, length of stay (LOS) at inpatient rehabilitation facility (IRF), and discharge destination following IRF stay, ... -
Pharmacokinetics of Bupropion and its Pharmacologically Active Metabolites in Pregnancy
Bupropion, an antidepressant and anti-smoking medication, is used for treatment of depression during pregnancy, however its efficacy as a smoking cessation aid in pregnancy has not been confirmed. The drug is extensively ...
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