Published ETD Collection
Recent Submissions
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Biomarkers of Human Exposure and Effect to Petrogenic Polycyclic Aromatic Hydrocarbons
Safety of seafood harvested from the Gulf of Mexico has been a primary concern since the 2010 Deepwater Horizon (DWH) oil spill. Petrogenic polycyclic aromatic hydrocarbons (PAHs) found in crude oil have the potential to ... -
Characterization of Aryl Hydrocarbon receptor and Kruppel-Like-Factor-6 interaction
The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor which regulates toxic response to environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Upon ligand activation, the ... -
Near-Infrared Light Reduces Glia Activation and Modulates Neuroinflammation in Brain of Diet-Induced Obese Mice
Obesity is one of the most prominent risk factors for Alzheimer’s Disease (AD); obesity and AD share several pathological features, in particular the neuroinflammation. Hippocampal neuroinflammation, in rodents, correlates ... -
Traumatized Through Healing: The Stigmatization and Misrecognition of Trauma Among American Physicians
Language shapes the way that we look at an issue and the words we choose to define a problem dictate how we address it. This dissertation focuses on the effects of trauma on physicians and analyzes how the professional ... -
Hypogonadism, Testosterone Replacement Therapy and Risk of Depression in Middle Aged and Older Men in the US
Hypogonadism is posited as a risk factor for depression. Limited evidence from randomized controlled trials (RCTs) suggests that testosterone replacement therapy (TRT) may improve depressive symptoms in hypogonadal men. ... -
Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
Oxidative stress (OS) induced stress signaler p38 mitogen-activated protein kinase (p38MAPK) activation and fetal membrane senescence are associated with parturition. Our study determined changes in multipotent pro-cell ... -
Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
The role of glutamate dehydrogenase (GDH) in disease has been exhibited in congenital hyperinsulinism, specifically, hyperinsulinism/hyperammonemia syndrome (HHS). GDH catalyzes the reversible deamination of glutamate to ... -
The Characterization of Mip1 DNA Polymerase
Mitochondria are the only organelle to possess their own DNA outside of the nucleus. A single polymerase is primarily responsible for the replication and repair of mtDNA. In humans and other animals, this enzyme is known ... -
Defining the Normal Range of Cerebrospinal Fluid Opening Pressure in Adults: A Systematic Review
It has been theorized that the visual changes observed in the astronaut population described by the Spaceflight Associated Neuro-ocular Syndrome (SANS) are related to elevated intracranial pressure (ICP). To better understand ... -
OmicsSpace: A Proposed Omics Data Plan for NASA Human Research and Clinical Investigations
Genetic mutations can be introduced during one’s lifetime through errors in DNA processing or as the result of environmental exposures. Astronauts can experience numerous environmental changes during spaceflight including ... -
The acute effects of propranolol on metabolic dysfunction in severely burned pediatric patients
Severe burn injury is a profound and lasting form of trauma. Owing to advances over the past several decades, burn injury is no longer thought of as a mortal injury. However, significant morbidity still persists in the ... -
Characterization of a Low-Fidelity Live-Attenuated Vaccine for Venezuelan Equine Encephalitis Virus
During RNA virus replication, there is the potential to incorporate mutations that affect virulence or pathogenesis. For live-attenuated vaccines, this has implications for stability, as replication may result in mutations ... -
Feto-Maternal Exosome Characterization, Trafficking and Function During Pregnancy and Parturition
Endocrine factors and signals of fetal organ maturation are well-reported determinants of the timing of birth and have been studied extensively in both humans and animal models. However, decades of research have not yielded ... -
Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
Sulfur dioxide is an endogenously produced gas, once thought to be solely toxic. More recent studies have demonstrated that at physiological concentrations however it can also have beneficial effects, such as inhibition ... -
Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
Sulfur dioxide is an endogenously produced gas, once thought to be solely toxic. More recent studies have demonstrated that at physiological concentrations however it can also have beneficial effects, such as inhibition ... -
Mast Cell Influence in the Progression of Post-burn Hypertrophic Scar Pathophysiology
Painful, motion-limiting hypertrophic scars (HTS) form after protracted wound healing in patients with severe full-thickness burns and pose difficult treatment challenges. Despite substantial reduction in postburn mortality, ... -
'Healthcaring': Learning to Resist the Logic of Letting Go through Arts-Based Curriculum in a Student-Run Free Clinic
Contemporary healthcare education does not adequately prepare students for some of the most persistent moral challenges of medical practice in the United States. Healthcare in the US includes practices and policies of ... -
Exploring the Use of Social Network Analysis On Physician Networks Created from Medicare Data through Studying the Use of Minimally Invasive Breast Biopsy Among Physicians: Descriptions, Regressions, and Network Models
Social Network Analysis (SNA) has been applied in a variety of scientific fields. In particular, SNA has been utilized with Medicare data to study the structure of physician networks. We utilized SNA to elucidate the ... -
POST-EXPOSURE TREATMENT OF MARBURG VIRUS ANGOLA DISEASE IN NON-HUMAN PRIMATES USING RECOMBINANT VESICULAR STOMATITIS VIRUS VECTORS
No licensed vaccines or treatments exist for Marburg virus (MARV) disease. As a preventative vaccine, a recombinant vesicular stomatitis virus (rVSV) expressing the Musoke strain glycoprotein (GP) of MARV protects macaques ... -
Characterization of a recombinant chimeric yellow fever 17D vaccine - dengue-4 virus
The disease dengue is caused by four genetically and serologically related virus termed dengue virus-1 to dengue virus-4 (DENV-1 to DENV-4) There are currently no licensed therapeutics, but there is a recently licensed ...
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