Published ETD Collection
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HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
(2020-08-01)Chronic HCV infection is the leading cause of steatosis (fatty liver disease) and hepatocellular carcinoma (HCC). The virus establishes a chronic infection in 70% of patients and infects approximately 71 million people ... -
Proviral Roles of Ebola virus VP35 Ubiquitination
(2022-05-01)Ebola virus’ structural protein VP35 is polyfunctional and plays vital roles in Ebola’s life cycle from antagonizing the host’s type I interferon pathway to acting as the polymerase co-factor. The mechanisms that regulate ... -
Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors
(2021-05-01)The discovery of G protein-coupled receptors (GPCRs) and the extensive second messenger systems associated with their activation has ushered in an enormously productive period in drug discovery. The extent to which around ... -
Opioid Prescribing and Opioid-Related Health Outcomes Among Cancer Survivors
(2023-05-01)The US population of older long-term cancer survivors—Americans who are free of cancer 5-years post-cancer diagnosis and not receiving cancer treatment—is growing. The prevalence of pain among cancer survivors after curative ... -
Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions
(2020-05-01)As fundamental determinants of neuronal function, voltage-gated Na+ (Nav) channels are important targets for therapeutic development against a wide range of health conditions. Dysfunction of Nav channels in the CNS is ... -
A Naturalistic Inquiry of Nigerian Immigrant Nursing Students’ Experiences in United States (U.S.) Baccalaureate Nursing Programs
(2020-05-01)Nigerian immigrant nursing students have been identified in the literature as having difficulty in making a transition to the teaching methods used in nursing programs in the U.S. Among the problems they experience are ... -
Employee Assistance Program and Occupational Health Providers’Perceptions and Experiences with Intimate Partner Violence in the Workplace: A Grounded Theory Study
(2020-05-01)Abstract:Title: Employee Assistance Program and Occupational Health Providers’ Experiences and Perceptions of Intimate Partner Violence in the WorkplacePurpose/Significance: Employee Assistance Program/Occupational Health ... -
The Roles of Estate Planning and Social Support in Racial/Ethnic Disparities in Advance Care Planning and End-of-Life Care
(2020-05-01)Advance Care Planning (ACP)– completing advance directives, discussing end of life care preferences, and assigning a durable power of attorney for healthcare – may be associated with improvements in quality of end of ... -
The Relationship Between Gastrointestinal Disease and Post-traumatic Stress Disorder in United States Military Veterans
(2020-05-01)This study examined relationship between gastrointestinal disease (GI Disease) and post-traumatic stress disorder (PTSD) in United States Military Veterans. Based upon literature and clinical practice data sources from ... -
Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity
(2020-05-01)A group of neurodegenerative diseases that are pathologically characterized by the presence of intracellular abnormal aggregation of α-Synuclein (α-Syn) in Lewy bodies (LBs) and Lewy neurites (LNs), are collectively known ... -
Efficient Identification and Comprehension of Molecular Pathways Associated with Irradiation Induced Hepatic Carcinogenesis
(2020-05-01)As human exploration into deep space continues to expand in the future, risk prediction for irradiation-induced diseases will become an increasingly important task. It will be critical to identify the biological effects ... -
An Exploration of School Nurses' Perspectives in Caring for Homeless Children
(2020-05-01)Naturalistic inquiry methodology was incorporated into a qualitative study designed to explore the experiences and perceptions of school nurses working with homeless, elementary school-aged children. The researcher employed ... -
Description of interactions of Ebola virus with a putative reservoir species using next-generation sequencing
(2020-05-01)Ebola virus (EBOV) causes a severe, often fatal disease in humans and nonhuman primates. Recently, EBOV has caused two very large outbreaks, one of which is ongoing in the Democratic Republic of the Congo. Bats are the ... -
Vector Competence of Aedes aegypti for Zika Virus and Effects of Colonization
(2020-05-01)The following dissertation aims to determine how vector colonization of influences the vector competence of Aedes aegypti for Zika virus (ZIKV) as well as the microbiome as a correlating factor. Ae. aegypti is the vector ... -
Profiling the Serotonin2 Receptor System Functional Capacity: Towards Identification of a Cocaine Use Disorder Biosignature
(2020-05-01)Vulnerability to developing a cocaine use disorder (CUD) starts with a background of genetics and environment and results in changes in neuroplasticity that leads to a greater drive to take cocaine. The intricate interplay ... -
Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
(2023-05-01)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and adapt long after it first emerged in 2019. As the causative agent of the coronavirus disease 2019 (COVID-19), a tremendous effort has ... -
Commercial Sexual Exploitation of Children and School Nursing: A Non-Experimental Quantitative Study
(2023-05-01)Underlying the healthy learning environments of our nation’s schools are students who are unwillingly entangled in the darkness of a form of human trafficking known as commercial sexual exploitation of children (CSEC). ... -
Differences between Men and Women in Risk Profile of commonly used metrics in Screening for Obstructive Sleep Apnea using NHANES data.
(2023-05-01)Obstructive Sleep Apnea (OSA) is a common chronic condition that is often underdiagnosed, especially in women due to differences in symptomology. OSA is diagnosed using polysomnography which is time intensive and impracticable ... -
Spike Processing and Protease Usage Effects on SARS-CoV-2 Pathogenesis
(2023-05-01)The emergence of SARS-CoV-2 and its subsequent variants have ignited a multitude of studies on the spike protein and its domains. While most studies focus on the impact of receptor binding domain changes, mutations in the ... -
A Naturalistic Inquiry Into the Lived Experience of Nurse Practitioners Who Have Full Practice Authority
(2023-05-01)Full Practice Authority (FPA) is one of three types of practice authority that a nurse practitioner (NP) can obtain through state licensure, depending on the state where the NP plans to practice. The American Academy of ...
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