Browsing Published ETD Collection by Title
Now showing items 44-63 of 499
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Carbon Catabolite Regulation of Yersinia pestis Pathogenesis
In order to survive in the unique environments associated with different aspects of the infectious cycle, Yersinia pestis evokes adaptive responses to concertedly regulate gene expression. The overall objective of this ... -
Cellular mechanisms that modulate kainate receptor trafficking and assembly
(2007-06-08)Kainate receptors (KARs) in the mammalian brain play a variety of physiological roles that require selective assembly, intracellular trafficking, and synaptic targeting. Cytoplasmic and non-cytoplasmic determinants that ... -
Cellular requirements for antibody production in a novel LPS-enhanced model of autoimmune myasthenia gravis
(2009-07-20)Bacterial lipopolysaccharide (LPS) is a T cell-independent adjuvant known to abrogate peripheral tolerance. For the first time, the potential of LPS to induce antigenspecific B cell responses to acetylcholine receptor ... -
Certified Nurse Midwives' Barriers Toward Sexual Health Screening Practices
Sexuality and sexual heath are important components of general health screenings. Reports of sexual health screening practices are limited to physicians, nurses and nurse practitioners. No research exists to describe ... -
Chagas disease, need and progress made in implementing donor blood screening in the United States.
(2007-08-01)Background: Chagas disease is a parasitic infection caused by Trypanosoma cruzi affecting 11 million people worldwide. The condition can be acquired via exposure of a wound or mucosa to infected feces from a reduviid bug, ... -
Change in positive emotion and recovery of functional status following stroke rehabilitation in older adults
(2010-04-26)Stroke is a leading cause of disability in the United States and represents a major public health challenge. Recovery of functional status following stroke is a primary focus for rehabilitation, and is an important health ... -
Changes in the prevalence of cognitive impairment among older Americans, 1993-2004: Overall trends and differences by race/ethnicity and socioeconomic status
(2010-03-03)Research indicates that the health of the older population in the United States, as measured by most dimensions, has improved over the past two decades. Population-level changes in health have been attributed to increases ... -
Characteristics of a healing environment as described by expert nurses who practice within the conceptual framework of Rogers’ Science of Unitary Human Beings: A qualitative study\r\n
(2008-02-14)The purpose of this study was to identify and describe characteristics of a healing environment from a nursing perspective. This qualitative study was conducted using an interpretive descriptive method consistent with a ... -
Characterization of a novel pro-apoptotic role for nuclear associated BCL-2
(2006-11-03)Both stroke and cancer are major public health problems that inflict immeasurable suffering to victims and their families. The treatment options currently in place for both stroke victims and cancer patients are limited. ... -
Characterization of Codon Optimized Wild Type TDP-43 Mediated Neurodegeneration in a Drosophila Model for ALS.
TAR DNA Binding Protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration-ubiquitin (FTLD-U). The exact mechanism by which TDP-43 ... -
Characterization of human IgA-inducing protein
(2009-03-12)Over the last several years there has been a great deal of progress in characterizing the role of dendritic cells (DCs) in the activation and modulation of B cells. DC-secreted chemokines can induce B cell trafficking to ... -
Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen, which affects both humans and livestock. RVFV belongs to the Bunyaviridae family, genus Phlebovirus and consists of a tripartite genome (L-, M- and S- ... -
Characterization of serum-induced CYP1A1 expression and activity in mouse embryo fibroblasts
(2005-07-07)The AhR is a ligand-activated transcription factor that mediates the toxic effects of environmental contaminants that include TCDD. Using a TCDD dose-response treatment in MEFs, we observed a super induction of CYP1A1 with ... -
Characterization of single-cycle flavivirus particles for use as a vaccine to prevent West Nile disease and to examine immune responses to flavivirus infection
(2009-08-28)West Nile virus (WNV) is responsible for the largest outbreak of viral encephalitis in the history of North America, yet there are no vaccines available to prevent this disease. To address these needs we have developed ... -
Characterization of the Burkholderia mallei ∆tonB Mutant and its Potential as a Backbone Attenuated Strain for Vaccine Development
In this study, a Burkholderia mallei ∆tonB mutant deficient in iron acquisition was constructed, characterized and evaluated for its protective properties in acute inhalational mouse models of glanders and melioidosis ... -
Characterization of the DNA repair role of the Saccharomyces cerevisiae NSE1 gene
(2008-05-14)In eukaryotes, the structural maintenance of chromosomes (SMC) complexes play important roles in chromosome dynamics. The Saccharomyces cerevisiae Smc5-Smc6 complex is composed of eight essential subunits and is particularly ... -
Characterization of the effects of Interferon gamma protein-10 (CXCL10) against the protozoan parasite Leishmania amazonesis
(2007-06-26)Leishmania amazonensis causes progressive disease in most inbred strains of mice. We have previously shown that L. amazonensis-infected C57BL/6 mice have profound impairments in expression of pro-inflammatory cytokines, ... -
Characterization of the entry mechanisms utilized by the alphavirus venezuelan equine encephalitis virus to infect mosquito cells
(2007-08-13)Venezuelan equine encephalitis eirus (VEEV) is a New World alphavirus that can cause fatal encephalitis in humans. VEEV is an enveloped, positive-strand RNA virus that is transmitted by a mosquito vector. Most research ... -
Characterization of the molecular and biological determinants of viral dissemination from the mosquito midgut: Yellow feber virus in Aedes aegypti
(2006-08-15)In order for a mosquito-borne virus to be transmitted from an infected mosquito to a vertebrate host, virus must disseminate from the mosquito midgut- the initial site of infection following uptake of an infectious bloodmeal- ... -
Characterization of the role of the innate immune system in the pathogenesis of chikungunya virus in mice
Chikungunya virus (CHIKV) is an alphavirus which causes a febrile illness in people that can induce a persistent and recurrent arthralgia. Recent outbreaks of CHIKV in tropical regions have caused millions of people ...