Browsing Published ETD Collection by Title
Now showing items 279-298 of 741
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Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway
(2008-12-18)Neuroblastoma is the most common extracranial solid tumor in infants and children. Our lab and others have shown trophic actions of gastrin-releasing peptide (GRP), and its analogue bombesin (BBS), in neuroblastomas. Our ... -
Gene expression microarray analysis of small, purified cell subsets
(2007-04-23)Gene expression microarray technology is potentially capable of examining all of the cellular processes at the mRNA level at a given moment. One major challenge in its applicability is that most biological samples are cell ... -
General physical preparedness of emergency and essential personnel
(2010-07-12)Emergency and disaster preparedness plans are an essential requirement for most organizations today due to the frequency and complexity of incidents such as disease outbreaks, natural disasters such as hurricanes, floods, ... -
A general scaffold for the synthesis of cysiherbaine and its analogues
(2008-12-03)Dysiherbaine 1 and a select number of structurally related compounds have been shown to have selective effects on ionotropic glutamate receptors (iGluRs). iGluRs are essential components in the central nervous system (CNS); ... -
Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras
Flaviviruses are positive-sense, single-stranded RNA viruses responsible for millions of infections annually. Primarily transmitted by ticks and mosquitoes, their associated diseases range from mild febrile infections to ... -
Genetic Determinants of ABCB1 Promoter Activity and Their Effects on Environmental Exposure
In utero exposure to xenobiotics, including medications and environmental agents, can lead to developmental and behavioral problems as well as cancer later in life. Efflux transporters, which are highly expressed in the ... -
Genetic Determinants of Junin Virus Attenuation
The New World arenavirus Junin (JUNV) is the causative agent of the Argentine hemorrhagic fever (AHF), a deadly disease endemic to central regions of Argentina. The live-attenuated Candid #1 strain of JUNV is currently ... -
Genetic determinants of NEIL2 transcription
(2008-03-20)The human genome is constantly damaged by reactive oxygen species (ROS) which produce a multitude of oxidative DNA lesions that can lead to mutations, genomic instability, and ultimately, to the development of cancer and ... -
Genetic diversity and taxonomical relationships among the tacaribe serocomplex viruses (family arenaviridae)
(2007-05-30)The three objectives of this dissertation were to 1) examine the natural host relationships and origins of the North American Tacaribe serocomplex viruses (family Arenaviridae), 2) extend our knowledge of the genetic ... -
Genotypic and Molecular Determinants in the Continued Evolution of West Nile Virus in the United States
Following the introduction of West Nile virus (WNV) into New York in 1999, the virus continues to evolve in the U.S. with the emergence, extinction, and co-circulation of multiple, distinct U.S. genotypes. Despite annual ... -
Genotypic and Phenotypic Determinants of Japanese Encephalitis Virus Geographical Expansion
Japanese encephalitis virus (JEV) consists of at least four geographically and epidemiologically distinct genotypes (GI-IV). Genotypes II and IV have been isolated in tropical Asia only, and GI has recently replaced GIII ... -
Giving voice to the vulnerable: Advocacy and oncology nursing
(2008-07-24)Despite common use of the term, there is no consensus among nursing professionals on a definition of advocacy, how to teach it, measure it, and determine its effectiveness. The purpose of this grounded theory study was to ... -
Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
HIV-1 infection of the nervous system causes various neurologic diseases. Synaptic degeneration is a critical underlying neurological pathology. However, the mechanism by which HIV-1 causes synaptic degeneration is unclear. ... -
Global Health, Social Justice, and Corporate Accountability
Chapter one of the dissertation contrasts libertarian theories to the theories of John Rawls and the human development approach favored by Martha Nussbaum and Amartya Sen. Libertarian theorists such as Robert Nozick, Murray ... -
Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
The aryl hydrocarbon receptor (AhR) is a cytosolic, ligand activated transcription factor commonly known for its role in environmental toxicant metabolism. However, the generation of AhR knockout (AhR-KO) mice has shown ... -
GOUT: An aeromedical clinical practice guideline
(2008-04-21)Through the completion of this capstone project, I am demonstrating the significance of gout in the United States of America, and in particular in the arena of aerospace medicine today. I have created a current clinical ... -
A grounded theory study of substance use patterns among homeless youth
(2009-07-13)A Grounded Theory Study of Substance Use Patterns among Homeless Youth\r\n\r\nPublication No.______________\r\nPhilisie Starling Washington, PhD\r\nThe University of Texas Medical Branch, 2009\r\n\r\nSupervisor: Carolyn ... -
Group III mGluR8 negatively modulates TRP channels
Several lines of evidence indicate group III metabotropic glutamate receptors (mGluRs) have systemic anti-hyperalgesic effects. We hypothesized this could occur through modulation of TRP channels on nociceptors. The following ... -
Growth Factors Up-Regulate Epithelial Stem Cells: Treatment Strategies for Colorectal Cancers
Colorectal-cancer is a leading cause of cancer deaths in United States. Accumulating evidence suggests that elevated progastrins (PG) increase the risk of colon carcinogenesis, however mechnaims involved remain ill-defined. ... -
Healing at the Margins: A Cultural/Historical Perspective on International Medical Graduates in the US Healthcare System
Foreign, or international, medical graduates make up about twenty five percent of current American medical trainees and twenty percent of physicians actively practicing medicine in the United States. In some specialties, ...