Browsing Published ETD Collection by Title
Now showing items 470-489 of 741
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Obesity, Diabetes, and Disability in Older Mexican Americans, 1993-2011
Increases in obesity have been observed in both men and women, for all age groups and major ethnic groups, and at all educational levels. However, in Mexican Americans, the increased level of obesity only partially accounts ... -
Occupational Health: Exploring Job Stress and Work Ability in Nurse Managers
Nurse managers provide key leadership toward reaching patient care and organizational goals in the new models of healthcare endorsed by the Institute of Medicine (2011). While much work had been reported in the literature ... -
OmicsSpace: A Proposed Omics Data Plan for NASA Human Research and Clinical Investigations
Genetic mutations can be introduced during one’s lifetime through errors in DNA processing or as the result of environmental exposures. Astronauts can experience numerous environmental changes during spaceflight including ... -
On Being A NASA Flight Surgeon
Flight surgeons are physicians that care for the varied medical needs of aviators, flyers, pilots and astronauts. This thesis constitutes a literature review as to the characteristics of flight surgeons including from a ... -
Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications
Traumatic brain injury (TBI) is a risk factor for the later development of Alzheimer’s disease (AD), although the mechanisms contributing to this increased risk are unknown. Insulin resistance is an additional risk factor ... -
Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
Burkholderia pseudomallei is a Gram-negative, intracellular pathogen and the etiological agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this ... -
Organ Donation in the United States
(2013-06-03)Introduction: The demand for donor organs far exceeds the number of donors. Approximately 18 people in the United States die every day waiting for an organ transplant. The purpose of this capstone is to describe the ... -
Outcomes of Selective Percutaneous Myofascial Lengthening Surgery (SPML) In Children with Lower Extremity Spasticity
Cerebral palsy (CP) is a neurodevelopmental condition defined as a disorder of posture and movement that is caused by a nonprogressive abnormality of an immature brain which can result in spasticity (Paneth, 2006; Pelligrino, ... -
Overexpression of Heat Shock Factor 1 Protects against Pathological Proteins in Neurodegenerative Diseases
A classical feature of neurodegenerative disorders is the accumulation of protein aggregates, such as TAR DNA/RNA binding protein (TDP-43) and superoxide dismutase 1 (SOD1), which lead to neuronal dysfunction and loss. ... -
Overuse of 3 Common Tests in the Elderly: Primary Care Physician (PCP) Variation, Associated Physician Characteristics, and Correlation of Overuse of Tests Within Physicians
Overuse of tests in the elderly is a nationwide problem that leads to patient harm. Some of the most commonly ordered tests are overused even though specific guidelines have been published and appropriately disseminated. ... -
Oxygen resuscitation does not ameliorate neonatal hypoxia/ischemia-induced edema
(2009-03-20)Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children. Although cerebral edema is a common outcome after HI, the mechanisms leading to the ... -
Paclitaxel nanoparticles for breast cancer therapy in pregnancy
Breast cancer can complicate pregnancy and result in fetal and maternal morbidity and mortality. These effects are often compounded by restrictions in the diagnosis and treatment of breast cancer due to implications on ... -
Pain, Disablement Process and Frailty among Older Adults in the United States: Findings from the National Health and Aging Trends Study
Background: Musculoskeletal pain is highly prevalent among older adults and the most common cause of disability. Objectives: To examine 1) whether sociodemographic characteristics, comorbidities, depression, obesity and ... -
Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis
(2003-03-26)Protozoan Leishmania is an important human pathogen that affects millions people worldwide. Investigation of experimental Leishmania infection in mice has been instrumental to our understanding of interactions between the ... -
Pathogenesis and transmission of Venezuelan equine encephalitis virus
(2006-04-03)Venezuelan equine encephalitis virus (VEEV) is an emerging arboviral pathogen that affects the Americas. Outbreaks can involve hundreds- of- thousands of equines and humans, spread over large geographic regions, and can ... -
Pathology and mechanisms of increased M.tb growth and dissemination during co-infection with HIV-1
Around one third of the world’s population is latently infected with Mycobacterium tuberculosis (M.tb). M.tb and HIV have a deadly synergy that occurs during co-infection. Individuals with HIV infection are at significantly ... -
PCP and conformational motifs: applications in predicting mechanical strength, allergenicity of proteins and vaccine design
The functions and properties of proteins are mainly determined by their amino acid sequences and 3-dimensional structures. Motifs composed of amino acids that are either continuous in sequence or cluster in space play ... -
PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
TP508 is a therapeutic peptide that represents a specific receptor-binding domain of human thrombin with many potential clinical applications. However, it shares several weaknesses common to peptides when administered ... -
Perceived Benefits and Barriers in Patients Diagnosed with Systemic Lupus Erythematosus Between 18 and 44 Years of Age: A Pilot Study
This study employed a cross-sectional, descriptive quantitative approach to identify perceived benefits of physical activity and perceived barriers to physical activity in female patients diagnosed with SLE between 18 and ... -
Perceptions of aggression in mental health clients
(2008-06-23)In mental healthcare identifying factors including those that exist within the client-caregiver alliance is important so that aggression can be eliminated or minimized. The naturalistic inquiry method answered the following ...