Browsing Published ETD Collection by Title
Now showing items 392-411 of 498
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S100A4 regulation and function
S100A4 is a calcium binding and tumor associated protein. Despite its critical roles in multiple aspects of cancer progression and non-malignant disease development, the investigations on the regulation of S100A4 are ... -
School-based telemental health at the University of Texas Medical Branch: A compilation and design of a standard operating procedures manual
(2010-05-18)Our nation is undergoing reform to close the gap on health care disparities within its population. Tendering services to everyone regardless of ability to pay will, no doubt, increase the number of people served; however, ... -
Secondary stress and coping experiences of partners of persons with oral cancer: A descriptive study
(2010-06-09)The purpose of this study was to explore the existence of Secondary Traumatic Stress (STS) in caregivers of persons with oral cancer, describe the nature of the experience of STS and its relationship to other variables of ... -
Sensorimotor disturbances in astronauts following space flight: Causes, evaluation, and countermeasures
(2010-08-15)Spaceflight induces a myriad of changes on the physiology of the human body. A cumulative result of many of these changes is sensorimotor dysfunction whereby small movements at the head level may lead to an exaggerated ... -
The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure
(2009-03-17)Repeated intermittent cocaine administration results in a progressive augmentation of motor stimulant responses to subsequent drug challenge. Neuronal adaptations underlying this enduring behavioral transformation, known ... -
Serotonin 5-HT<sub/>2C</sub> receptors: Role in (+)-MDMA sensitization and distribution in the ventral tegmental area
(2005-03-09)Serotonin (5-HT) released consequent to acute (+)-3,4-methylenedioxy-methamphetamine [(+)-MDMA; \"ecstasy\"] administration stimulates 5-HT<sub/>2C</sub> receptors (5-HT<sub/>2C</sub>R) to exert inhibitory influence on ... -
Short-term effects of a nutrition education program on food choices in adolescents at risk for type 2 diabetes
(2009-10-26)Type 2 Diabetes (T2D) among adolescents has increased over the past several decades. Genetic susceptibility may play a role in the occurrence of this illness. However, the current epidemic of T2D among adolescents reflects, ... -
Signaling crosstalk in cancers
(2008-04-03)Deregulation of cellular signaling contributes to the malignant phenotype of cancer. In this dissertation, cross-talk among oncogenic signaling pathways was investigated in two common human cancers. \r\n Pancreatic cancer ... -
Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
(2008-12-17)Our goal is to increase the number of immature umbilical cord blood stem cells (UCBSCs) for hematopoietic transplantation. Towards this goal, our lab adapted a culture technique to grow immature CD133+ UCBSCs (CD133+ ... -
Simulating Space Radiation for Testing Shielding Material Effectiveness
The space radiation environment poses health risks to astronauts. There are three sources of space radiation: trapped radiation, Solar Particle Events, and Galactic Cosmic Rays (GCR) and these sources consist primarily ... -
Skeletal Muscle Protein Metabolism and Molecular Responses to Endurance Exercise and Nutritional Interventions
It has been suggested that the gradual loss of muscle mass observed with healthy aging is the result of a resistance of aged muscle tissue to normally potent anabolic stimuli. Recent evidence indicates an age-related ... -
Smartphone Application Interventions to Increase Weight Loss: A Systematic Review
The obesity epidemic has reached a critical level in this country. The most recent estimates state that 78.6 million adults in the U.S. are obese. As this number is expected to continue to rise in the coming years, new ... -
Socios para su Salud – A program evaluation of a community-based health education program in Cameron Park, Texas
(2009-07-17)INTRODUCTION: Management of chronic diseases such as diabetes requires a multi-faceted approach. Diabetes care involves educating patients on the disease process, their medication regimen, adequate blood sugar monitoring, ... -
Solid phase peptide synthesis and TLR-5 activity analysis of pertide fragments from the Salmonella muenchen flagellin protein
(2005-08-18)Drug design strategies begin by determining the simplest ligand necessary to activate a receptor of interest. The Toll-Like Receptor-5 (TLR-5) is an attractive target for pharmaceutical modulation because it initiates an ... -
Sphingomyelinases and Lysosomal Trafficking in Ebolavirus Entry
(2011-09-27)Ebolavirus (EBOV) is a negative sensed, single-strand filovirus which causes up to 90% mortality. Despite increasing outbreaks over the past decade, no approved vaccines or therapies exist. One drug treatment strategy is ... -
STAT3-protein interactions in IL-6/gp130 signaling
(2008-08-20)The Signal Transducer and Activator of Transcription 3 (STAT3) is a central transcription factor downstream of IL-6/gp130 signaling. This thesis investigates how STAT3 regulates IL-6 signal transduction by interacting with ... -
The stories we sell: A narrative analysis of direct-to-consumer pharmaceutical advertising\r\n
(2007-03-12)This dissertation focuses on the issue of direct-to-consumer (DTC) television advertising for prescription drugs. First, it explores the terms and categories currently used to understand and debate this issue. Then, it ... -
Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus
Pestiviruses are single-strand positive sense RNA viruses that belong to the flaviviridae family. They express their genome as a single polypeptide that is subsequently cleaved into individual proteins by host- and ... -
Structural and biophysical studies of HIV-1 Rev protein
(2006-03-20)Rev is a key HIV-1 virus regulatory protein, which exports the unspliced and partially\r\nspliced viral mRNA out of the nucleus, thereby inducing the switch from the early phase\r\nto the late phase of the viral replication ... -
Structural and functional studies of sodium/dicarboxylate cotransporters
(2008-06-23)The sodium/dicarboxylate cotransporter (NaDC1) is found on the apical membrane of the kidney proximal tubule and the small intestine. It carries various di- and tri- carboxylates such as succinate, á-ketoglutarate and ...