Browsing Published ETD Collection by Title
Now showing items 627-646 of 741
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TAME Health: Testing Activity Monitors’ Effect on Health
To promote physical activity in healthcare, the American Heart Association suggests 5 A’s counseling and technology-based resources for individuals at moderate risk for cardiovascular disease. Pedometers are low-tech devices ... -
Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
Voltage-gated sodium (Nav) channels are responsible for initiation and propagation of action potentials, which contribute to control of neuronal excitability. Malfunction of specific Nav channel isoforms is associated with ... -
Taser subjects: Identification of high-risk individuals
(2008-04-21)Taser® devices are used by many police forces as a nonlethal means of subduing individuals. These devices use conducted electrical energy to cause neuromuscular incapacitation. Tasers have been associated with adverse ... -
TDP-43 and its role in neurodegeneration
Ubiquitinated TDP-43 (TAR DNA Binding Protein) inclusions are a hallmark of ALS (amyotrophic lateral sclerosis) and FTLD-TDP-43 (frontotemporal lobar degeneration with ubiquitin inclusions). These diseases share a similar ... -
The Activation of the Inflammasome during Rickettsial Infection
Rickettsiae are Gram-negative, obligately intracellular bacteria that infect endothelial cells and macrophages. The molecular mechanisms involved in interaction of rickettsiae with macrophages, however, remain poorly ... -
The acute effects of propranolol on metabolic dysfunction in severely burned pediatric patients
Severe burn injury is a profound and lasting form of trauma. Owing to advances over the past several decades, burn injury is no longer thought of as a mortal injury. However, significant morbidity still persists in the ... -
The Anti-Inflammatory Effects of Low Concentrations of Carbon Monoxide in Human Airway Smooth Muscle Cells
Carbon monoxide (CO) has emerged as a potential therapy exerting cytoprotective effects in models of inflammatory diseases including asthma. Similar studies implicate human airway smooth muscle cells (HASMC) as contributing ... -
The Association Between Sex Hormone Binding Globulin And C-Reactive Protein Levels in Premenopausal Women
Uncertainty remains regarding the effect of female sex hormones on the immune system and inflammation process. Sex Hormone Binding Globulin (SHBG) modulates the relative effects of estrogen and testosterone, specifically ... -
The Biotechnological Applications of an Insect-Specific Alphavirus
The coupling of viral and arthropod host diversity with evolving methods of virus discovery has resulted in the identification and classification of a growing number of novel insect-specific viruses (ISVs). These viruses ... -
The broken genome: Merging cutting edge technologies for a molecular understanding of the Flock House virus defective interfering particle.
Defective RNAs are natural versions of a viral genome that have been truncated or rearranged by non-homologous recombination. While not encoding for functional viruses, they can be amplified and co-passaged with the wild-type ... -
The Characterization of Mip1 DNA Polymerase
Mitochondria are the only organelle to possess their own DNA outside of the nucleus. A single polymerase is primarily responsible for the replication and repair of mtDNA. In humans and other animals, this enzyme is known ... -
The development and use of cutting edge next generation sequencing methodologies to study RNA viruses
With new next generation sequencing technologies and methodologies being published often, our ability to sequence viruses and host transcriptomes (in response to viral infection) has expanded – driving virology forward. ... -
The development of a reverse genetics system for Machupo virus
The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV), is a highly lethal viral pathogen with no approved vaccine or therapeutic to limit infection or outbreaks. Following implementation of rodent ... -
The Development of an Emergency Response Plan for Medical Contingencies during Commercial Spaceflight at the Houston Spaceport
Commercial spaceflight has grown increasingly prominent over the last decade. Yet despite the obvious successes, commercial spaceflight is still in its relative infancy, and mishaps in the industry may be enough to lose ... -
The direct effects of estradiol and several xenoestrogens on cell numbers of early- vs. late-stage prostate cancer cells
Prostate cancer is the most common non-cutaneous cancer among men, and diethylstilbestrol (DES) is an estrogen that has been used clinically to combat advanced tumors. Estrogens can indirectly decrease androgen production ... -
The Early Events and Long-Term Effects of Perinatal Cerebral
Neonatal hypoxia-ischemia (HI) affects 60% of low birth weight infants and up to 40% of preterm births. Due to the increasing incidence of preterm and low birth weight infants and the lack of adequate treatment for HI, ... -
The Effect of Human Patient Simulation on Medical-Surgical Nurses’ Self-Efficacy in Cardiac Emergency Management
Over 200,000 in-hospital cardiac arrests (IHCA) occur each year, making code management education and training a priority for first responders within the hospital. Medical-surgical nurses, who are frequently the first ... -
The Effect of Modeled Microgravity and Radiation on Epstein-Barr Virus in a Modeled Spaceflight System
Epstein-Barr virus (EBV) is the causative agent of mononucleosis and is also associated with several malignancies, including Burkitt’s lymphoma, Hodgkin’s lymphoma, nasopharyngeal carcinoma, and post-transplant lymphoproliferative ... -
The Effect of Obesity on Disability and Mortality in Mexican Older Adults
(2016-04-29)Objective: To examine the effect of obesity on incidence of disability and mortality among non-disabled older Mexicans at baseline. Methods: The sample included 8,415 Mexicans aged ≥50 years from the Mexican Health and ... -
The Effect of Protein Blend Supplementation and Resistance Exercise on Skeletal Muscle Growth and Adaptation
The goal of this project was to determine the efficacy of a new protein supplement to improve muscle growth and strength when ingested following exercise. The hypothesis is that novel supplementation of mixed dietary ...