Browsing Published ETD Collection by Title
Now showing items 223-242 of 758
-
Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
(2007-09-14)The clinical manifestations of HME caused by Ehrlichia chaffeensis, a Gram-negative, LPS-lacking bacterium, including toxic shock-like syndrome and liver injury in the absence of overwhelming bacterial burdens, has led to ... -
Elevated temperature alters cytokine output and c-Jun N-terminal kinase signaling downstream of toll-like receptor activation
Fever is a fundamental and important response to infection. Previous studies have shown that alterations in temperature can alter the phenotype of innate immune cells, such as phagocytic ability, but the effects of elevated ... -
Elucidation of Mechanisms of Host Immunity against Orientia tsutsugamushi in a Newly Developed Murine Model
Scrub typhus, caused by a Gram-negative obligately intracellular coccobacillus, Orientia tsutsugamushi, is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each ... -
EMOTIONAL HEALTH AND TEENAGE PREGNANCY IN GALVESTON INDEPENDENT SCHOOL DISTRICT HIGHSCHOOLERS
In Galveston County in 2011 there were 15.9 live births per 1000 girls aged 15-17 years old, which is higher than the national average. The purpose of this research was to assess the role of emotional health, specifically ... -
Employer-based health insurance in the United States from 1920-present: The fall of an empire
(2006-12-06)The United States is the only industrialized nation that relies almost exclusively on private employers to fund health care. As this thesis will set out to demonstrate, the ability of private employers to fund this burden ... -
Engineering functionalized gold nanoparticles as a molecular-specific contrast agent to enhance optoacoustic detection of breast cancer cells
(2008-12-02)Molecular targeting of malignant tumors is a promising field of research that could potentially revolutionize the diagnosis and treatment of many types of cancer including breast. Delivering molecular specific contrast ... -
Enhancing the Data, Information and Knowledge from Proteomics Experiments through Biomedical Informatics
A systems approach to understanding disease begins with data that contains information from which knowledge is developed and ultimately provides wisdom and understanding to human health and disease. Systems biology is a ... -
EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
The recent discovery of a new family of cAMP sensor proteins, exchange protein activated by cAMP (EPAC), ushered in a new era in cAMP signaling. EPAC is composed of two main isoforms, EPAC1 and EPAC2, whose roles in mediating ... -
Epidemiology and clinical investigation of West Nile Virus encephalitis in Houston, Texas
(2006-08-17)In 2002, West Nile virus (WNV) appeared in Houston. Retrospective medical chart reviews were completed for 172 WNV cases hospitalized in the Houston area between 2002 and 2004; 113 had encephalitis (including 17 fatal ... -
Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in a university medical center day care facility
(2009-05-02)BACKGROUND: Few data are available on MRSA colonization in day care. We performed a study in a medical university child care center to determine the epidemiology of MRSA in this population. \r\n\r\nMETHODS: A cross ... -
Epigenetic Modulation of Synaptic Resilience in Alzheimer’s Disease
Some individuals, here referred to as Non-Demented with Alzheimer’s Neuropathology (NDAN), retain their cognitive function despite the presence of amyloid plaques and tau tangles typical of symptomatic Alzheimer’s Disease ... -
Epigenetic Regulation of Neurogenesis in Non-Demented Humans with Alzheimer’s Disease Neuropathology
This project was designed to investigate the role of neurogenesis and its epigenetic regulation by microRNA in the preservation of cognition against Alzheimer’s disease. This was accomplished by comparing by immunohistochemistry ... -
ER Stress is Linked to the Regulation of Hepatic Gluconeogenesis and Phosphatidylinositol 3-kinase/Akt Signaling Post Burn Injury
Burn injury is a severe form of trauma that causes changes in glucose metabolism. Glucose metabolism is controlled during early burn injury but later results in stress induced diabetes. We have shown that this is due to ... -
Erythropoietin for the Treatment of Porphyria Cutanea Tarda in End Stage Renal Disease
Porphyria Cutanea Tarda (PCT) is an iron-related disease that results from acquired inhibition of hepatic uroporphyrinogen decarboxylase (UROD), the fifth enzyme in the heme biosynthetic pathway. Clinically, PCT presents ... -
The essence of the experience of polypharmacy in the life-world of the community dwelling elder
(2008-02-29)Thirteen percent of the United States’ population is 65 years of age and older, and\r\nconsumes 33% of prescribed medications and 40% of over the counter medications. Most\r\nresearch addressing polypharmacy in the elderly ... -
Essentiality of Mitochondrial Genome Integrity in Cell Survival
(2012-05-30)The mitochondrial genome encodes 22 tRNAs, 2 rRNAs, and 13 polypeptides that are subunits of the electron transport chain involved in oxidative phosphorylation. Because of its proximity to source of ROS generation and its ... -
Estradiol and MDMA affect the susceptibility and immune response to genital herpes and genital herpes immunization
(2009-08-26)Herpes simplex virus type 2 (HSV-2), the most frequent cause of ulcerative genital herpes disease, has infected nearly one-in-five Americans and is even more prevalent in the developing world. The virus is also known to ... -
Evaluating Case Study Based Learning in Transgender Healthcare
Recent social changes in the United States has created a stage for a more widely accepted view towards transgender individuals. LGBT, specifically transgender, communities often experience significant disparities in the ... -
Evaluating Comorbidity Indices for Predicting Post-Acute Outcomes
Comorbidities are defined as acute or chronic medical conditions that an individual has in addition to his or her primary diagnosis. These comorbid conditions can affect a patient’s prognosis across the continuum of care. ... -
Evaluating Seeding Galveston: Assessing Food Security and Health-Related Outcomes
Program evaluation is a crucial step in the success of community-based programs, as it allows stakeholders and community organizations to determine the success of our efforts and make changes where necessary to improve our ...