Browsing Published ETD Collection by Title
Now showing items 403-422 of 758
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A mechanism for SCA10 neurodegeneration due to intronic repeat expansion
(2006-03-26)Spinocerebellar ataxia type 10 (SCA10) is the second most prevalent ataxia in Mexico and Brazil. Phenotype of the disorder first occurs around the third to fourth decade, generally after procreation, resulting in a highly ... -
Mechanism of action of AexU, a new type III secretion system effector from an emerging human pathogen Aeromonas hydrophila
(2010-07-08)Our laboratory first reported the complete sequence of the type III secretion system (T3SS) from a diarrheal isolate SSU of A. hydrophila. We identified an effector protein (designated as AexU) of the T3SS, which exhibited ... -
A mechanism of activation of c-MET receptor tyrosine kinase
(2006-06-23)c-MET receptor tyrosine kinase-mediated signaling governs numerous important cellular responses including cellular proliferation, differentiation, migration and apoptosis. Deregulation of these signals result in malignant ... -
Mechanism of local IL-6 production and its role in accelerating vascular inflammation leading to aortic diseases
(2008-12-03)Vascular inflammation plays a significant role in aortic diseases and involves enhanced recruitment and local activation of circulating monocytes along with cytokine production, but the mechanisms responsible for these ... -
Mechanism of Metformin Action in Dermal Fibroblasts
Burn injury is a significant problem that affects approximately half a million people in the U.S. annually. One of the major complications emerging from burn injury is hyperglycemia, which can last for weeks following the ... -
Mechanism of transmissible gastroenteritis virus nsp1-mediated translation inhibition
The non-structural protein 1 (nsp1) proteins of several coronaviruses share a common property to inhibit host gene expression, but use different mechanisms to exert this function. Unlike the nsp1 protein of SARS coronavirus, ... -
Mechanisms and Genetic Determinants of Alphavirus Infection of Mosquito Vectors
Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne disease that has caused hundreds-of-thousands of human and equine cases. Since epizootic strains have historically been the largest public health threat, the ... -
Mechanisms of attenuation of the live Junin virus vaccine strain, Candid #1
Millions of individuals are at risk of arenavirus infection worldwide, with untreated infections often resulting in potentially lethal disease. Junin virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), ... -
Mechanisms of Blood Flow Restriction Exercise in Skeletal Muscle Adaptations
The maintenance of skeletal muscle mass is crucial for human health and long term survival. However, the aging process is associated with an involuntary loss of muscle mass and the inability to maximally stimulate muscle ... -
Mechanisms of Dysregulated Alternative Splicing in Cardiac and Skeletal Muscle under Diabetic Conditions
Under diabetic conditions, cardiac and skeletal muscle undergoes changes that can lead to cardiomyopathy and myopathy respectively. Diabetes patients suffer from skeletal muscle weakness and atrophy. Diabetic cardiomyopathy ... -
Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
Monophosphoryl lipid A (MPLA) is a Toll-like receptor 4 agonist that has been approved for use as a vaccine adjuvant in humans. In these studies, we evaluated the effect of MPLA treatment on the innate immune response to ... -
Mechanisms of imporvement following functional inhibition of nitrosative stress after brun and smoke-induced acute lung injury
(2008-07-28)Severe trauma, caused by flame burn and smoke (B + S) inhalation induces acute lung injury (ALI) and results in the loss of pulmonary function. A cascade of molecular and cellular events initiates the formation of reactive ... -
Mechanisms of improvement following functional inhibition of neutrophil infiltration after spinal cord injury
(2006-12-06)Spinal Cord Injury (SCI) is a traumatic event that results in loss of function below the level of injury, and other dysfunctions including pain syndromes, both above and below the level of the lesion. A cascade of biochemical ... -
Mechanisms of increased microvascular permeability during acute Rickettsiosis
(2007-11-02)Rickettsial diseases represent some of the most severe bacterial infections in man including Rocky Mountain spotted fever and epidemic typhus. Rickettsiae primarily target the microvascular endothelium leading to increased ... -
Mechanisms of methylenedianiline toxicity to rat biliary epithelial cells
(2001-05-06)Methylenedianiline (4,4’-diaminodiphenylmethane, DAPM), a compound used to produce polyurethanes and epoxy resins, rapidly injures biliary epithelial cells (BEC) of rats in vivo. DAPM also increases biliary inorganic ... -
A mechanistic examination of the metabolic regulation of insulin resistance, sarcopenia, and osteoporosis
(2007-11-14)Aging is associated with a number of physiological changes, including increased risk of insulin resistance and type 2 diabetes mellitus (T2DM), decreased muscle mass and strength, and decreased bone mass and bone mineral ... -
Media induced anxiety in the active duty medical clinic setting: A pilot study
(2009-05-21)Media stimuli have long been used in the research community to evaluate autonomic responses among subpopulations. Prior to the terrorist attacks of 9/11, the majority of research had been focused on war veterans, rape/crime ... -
Medical and public health considerations in U.S. national disaster planning--The \"All-Hazards\" approach
(2010-07-12)Our nation faces many threats in this modern era, from natural disasters such as hurricanes to man-made disasters such as bioterrorism. Over the past 10 years, our disaster preparedness and response have evolved, though ... -
Medical Constraints in Spaceflight: Venturing Beyond Low Earth Orbit
NASA has generated a list of thirty-three gaps in medical capability that need to be addressed in order to extend the current model of medical care used in spaceflight in low-earth orbit to a model of medical care that ... -
Medical error: Overcoming barriers to truthful disclosure
(2007-03-09)The Institute of Medicine’s report on medical errors revealed a degree of fallibility in health care that was previously unrecognized. One explanation for the\r\ngeneral ignorance about the threats to patient safety and ...