Browsing Published ETD Collection by Author "Barral, Jose"
Now showing items 1-9 of 9
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Molecular Basis of Mammalian Prion Protein Misfolding
Diaz Espinoza, Rodrigo 1979-Prions are aberrantly folded proteins that are able to self-propagate their abnormal conformation using the normally folded protein as substrate. In mammals, the only known prion protein is PrP. The misfolding of PrP is a ... -
Molecular Basis of Prion Pathogenesis and Development of a Novel Therapeutic Strategy
Mukherjee, Abhisek 1982-Prion diseases are fatal neurodegenerative disorders characterized by a long pre-symptomatic phase followed by rapid and progressive clinical phase. Although rare in humans, the unconventional infectious nature of the ... -
Novel Effects of Simvastatin on Uterine Fibroids
Borahay, Mostafa A.Uterine fibroids (also known as leiomyomas) represent a common gynecologic problem with a significant medical and economic burden. Unfortunately, no satisfactory long-term medical treatment is currently available. Statins ... -
Procollagen Biosynthesis and Osteoblast Malfunction in the G610C Mouse Model of Osteogenesis Imperfecta
Felts, LynnOsteogenesis imperfecta (OI) is a hereditary disease that disrupts bone formation and function resulting in skeletal deformities and fragile bones. OI is diagnosed based on clinical and radiological examination, with patient ... -
The Early Events and Long-Term Effects of Perinatal Cerebral
Krishnan, Smitha 1984-Neonatal hypoxia-ischemia (HI) affects 60% of low birth weight infants and up to 40% of preterm births. Due to the increasing incidence of preterm and low birth weight infants and the lack of adequate treatment for HI, ... -
The mental health advantage of Latino neighborhoods: Investigating the role of social resources, stressful exposures, and neighborhood perceptions in the Latino composition-mental health relationship among Mexican-descent residents in high and low Latino composition neighborhoods of Texas City, Texas
Shell, Alyssa MarieThis dissertation investigates the relationship between neighborhood Latino composition and mental health. Emerging evidence suggests that high Latino composition may protect Latino residents against a variety of negative ... -
The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
Hedgepeth, Serena ClarkThe inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitously expressed endoplasmic-reticulum (ER)-resident calcium channel. Calcium release mediated by IP3Rs influence many signaling pathways including those regulating ... -
The UNC-45 molecular chaperone: Its interactions with myosin and its thermosensing properties
Bujalowski, PawelIn order to perform their biological functions, proteins must fold into a defined structure which is termed the “native state”. In some cases proteins can acquire the native structure spontaneously; however for others ... -
XPC Haplotypes Alter DNA Repair Capacity and Levels of Genetic Damage
Rondelli, Catherine MichelleXeroderma pigmentosum complementation group C (XPC) is the key recognition factor of DNA damage in global genome nucleotide excision repair (NER). The disease Xeroderma pigmentosum (XP) results from mutations leading to ...