DSpace at UTMB: Recent submissions
Now showing items 1-20 of 10932
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The role of Hsp60 in Amyloid beta toxicity: Relevance to Alzheimer’s disease
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder leading to dementia, affecting millions of individuals worldwide. Currently, there are no successful disease-modifying therapies, due to the complexity ... -
The role of Hsp60 in Amyloid beta toxicity: Relevance to Alzheimer’s disease
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder leading to dementia, affecting millions of individuals worldwide. Currently, there are no successful disease-modifying therapies, due to the complexity ... -
The Role of Arginine Vasopressin Receptor 2 in Microvascular Hyperpermeability During Severe Sepsis and Septic Shock
Sepsis compromises more than 18 million lives worldwide every year. Moreover, methicillin-resistant Staphylococcus aureus (MRSA) sepsis is one of the most severe types. Despite efforts to provide novel therapies for sepsis, ... -
Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
The aryl hydrocarbon receptor (AhR) is a cytosolic, ligand activated transcription factor commonly known for its role in environmental toxicant metabolism. However, the generation of AhR knockout (AhR-KO) mice has shown ... -
Exerting Capacity: A Grounded Theory Study of the Perspectives of Bedside Registered Nurses about Patient Safety in the Adult Acute Care Environment
The concept of patient safety has become a priority focus in healthcare research since 2000 following the release of the Institute of Medicine’s (IOM) (1999) report To Err Is Human: Building a Safer Health System. Despite ... -
An Ethnographic Study of Women Using HypnoBirthing: The Mongan Methodg
The purpose of this ethnography was to explore the values, beliefs and perinatal practices of women, who utilized HypnoBirthing. The aim was to explain the culture of HypnoBirthing through women’s perceptions of their ... -
Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras
Flaviviruses are positive-sense, single-stranded RNA viruses responsible for millions of infections annually. Primarily transmitted by ticks and mosquitoes, their associated diseases range from mild febrile infections to ... -
Ehrlichia chaffeensis Type 1 Secreted Effector TRP47 is a Novel SUMOylated Nucleomodulin
Ehrlichia chaffeensis secretes immunodominant and immunoprotective protein effectors into the host cell using a type I secretion system. The best-characterized of these effectors are the tandem repeat proteins (TRPs). In ... -
Mentoring Up: A Classical Grounded Theory Exploring the Proteges Perceptions of Nurse-to-Nurse Mentoring
Mentoring is widely advocated as a positive relationship in the nursing literature. The literature abounds with opinion-based, descriptive articles addressing mentoring, however few articles are theoretically and research ... -
Amino Acid Sensing in Muscle: Role of the lysosome and the effect of protein supplementation on improving amino acid sensitivity in aging muscle
Protein ingestion is a well-studied stimulus for increasing skeletal muscle protein synthesis. Only recently has the mechanism for this phenomenon been elucidated at the cellular level. To this point, most of the mechanistic ... -
The Effects of Blast-Induced Neurotrauma on Blood-Brain Barrier Permeability, Cell-Cell Junction Protein Levels and the Role of Peroxynitrite
Traumatic brain injury is one of the most common injuries presented in emergency departments in the U.S.. While mild traumatic brain injury (TBI) is often not reported or treated it may still result in significant ... -
TRANSLATING BIOMEDICAL RESEARCH DATA TO KNOWLEDGE THROUGH BIOINFORMATICS
In this dissertation, we present the application of biomedical informatics, including data mining and knowledge discovery, to extract knowledge from genomics, transcriptomics, and clinical data. To improve our understanding ... -
Group III mGluR8 negatively modulates TRP channels
Several lines of evidence indicate group III metabotropic glutamate receptors (mGluRs) have systemic anti-hyperalgesic effects. We hypothesized this could occur through modulation of TRP channels on nociceptors. The following ... -
The traditionally protective cystathionine gamma-lyase/hydrogen sulfide pathway contributes to pathological retinal neovascularization in oxygen-induced retinopathy
CSE is a key enzyme involved in the production of H2S and glutathione. CSE has been shown to protect against oxidative stress, attenuate ischemia/reperfusion injury, and promote angiogenesis, functions which are typically ... -
ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
Ataxia-Telangiectasia Mutated (ATM), a member of the phosphatidylinositol 3 kinase-like kinase family, is a master regulator of the double strand DNA break-repair pathway after genotoxic stress. Here we found ATM serves ... -
Characterization of a Newly Identified Alphavirus, Eilat Virus
Most alphaviruses are mosquito-borne and exhibit a broad host range, infecting many different vertebrates including birds, rodents, equids, humans, and nonhuman primates as well as mosquito species encompassing at least ... -
Identification of Image-based Markers for Oral Pre-cancers and Cancers using in-vivo Multimodal Imaging
The five-year survival rate for oral cancer is 57% and highly correlated to the stage at diagnosis. Early diagnosis is challenging with current clinical approach of detection based on visual conventional oral examination ... -
Scrub typhus: Epidemiology, Diagnosis, Treatment, Prevention and Control in the Asia-Pacific Area and Worldwide
The long term goal of this study is to develop effective measures to control and even eradicate scrub typhus and other related infectious diseases. Scrub typhus is a serious public health problem in the Asia-Pacific area. ... -
Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
Voltage-gated sodium (Nav) channels are responsible for initiation and propagation of action potentials, which contribute to control of neuronal excitability. Malfunction of specific Nav channel isoforms is associated with ... -
Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
CD8+ T cells play a central role in immunity against intracellular pathogens and cancer.Vaccines that elicit robust CD8+ T cell responses are desirable for protection against such infectious diseases and cancers. Subunit ...