DSpace at UTMB: Recent submissions
Now showing items 1-20 of 10952
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
Addictive disorders are a collection of maladaptive behaviors characterized by the uncontrolled use of a rewarding substance. These include substance use disorders, binge eating disorder, certain subtypes of obesity, ... -
Modulation of Host BRD4 to Repress HIV Replication in Myeloid Cells: Major HIV Reservoirs in Central Nervous System
Brain-resident microglia and myeloid cells (perivascular macrophages) are important HIV reservoirs in vivo, especially in central nerve system (CNS). Despite anti-retroviral therapy (ART), low-level persistent HIV replication ... -
Ehrlichia chaffeensis E3 Ligase TRP120 Ubiquitinates Tumor Suppressor FBW7 for Degradation to Promote Infection
Ehrlichia chaffeensis (E. chaffeensis) exploits evolutionarily conserved Notch and Wnt host cell signaling pathways to downregulate innate immune host defenses and promote infection. The multifunctional E. chaffeensis ... -
Rickettsia prowazekii and its ‘Junk DNA’: The Identification and Characterization of Small RNAs
As the etiologic agents of Rocky Mountain spotted fever and epidemic typhus, Rickettsia are obligate intracellular Gram-negative pathogenic bacteria. Genomic sequencing determined that ~24% of the Rickettsia prowazekii ... -
Outcomes of Selective Percutaneous Myofascial Lengthening Surgery (SPML) In Children with Lower Extremity Spasticity
Cerebral palsy (CP) is a neurodevelopmental condition defined as a disorder of posture and movement that is caused by a nonprogressive abnormality of an immature brain which can result in spasticity (Paneth, 2006; Pelligrino, ... -
HEALTH CARE, AGING, AND END OF LIFE: USING COMMUNITY BIOETHICS DIALOGUES TO PROMOTE INDIVIDUALIZED PERSONAL DECISIONS AND ADVANCE CARE PLANNING
In 1976, the New Jersey Supreme Court ruled that Joseph and Julia Quinlan could authorize removal of life support from their comatose daughter. Since that critical ruling, every state has passed legislation allowing ... -
Translational Frontiers for Chikungunya Virus: New World Epidemic, New Strains, New Therapeutic Targets
Chikungunya virus (CHIKV) infection results in chikungunya fever (CHIKF), marked by sudden onset of high fever, rash, and debilitating polyarthritis and polyarthralgia, which can last for months to years. Despite the severe ... -
Translational Studies of Acute and Chronic Traumatic Brain Injury: Molecular Profiling of Tissue and Biofluids
Traumatic brain injury (TBI) is a leading contributor to the global burden of disease. Despite the growing awareness of TBI and years of research into biomechanics and pathophysiologic mechanisms, there is still a lack of ... -
Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
Crohn’s Disease (CD) and Ulcerative Colitis (UC), the two major forms of Inflammatory Bowel Disease (IBD), are multifactorial autoimmune diseases caused by an abnormal immune response to gut microbiota in genetically ... -
Erythropoietin for the Treatment of Porphyria Cutanea Tarda in End Stage Renal Disease
Porphyria Cutanea Tarda (PCT) is an iron-related disease that results from acquired inhibition of hepatic uroporphyrinogen decarboxylase (UROD), the fifth enzyme in the heme biosynthetic pathway. Clinically, PCT presents ... -
Evaluating Case Study Based Learning in Transgender Healthcare
Recent social changes in the United States has created a stage for a more widely accepted view towards transgender individuals. LGBT, specifically transgender, communities often experience significant disparities in the ... -
Studying the biology of, and developing countermeasures to, a tick-transmitted hemorrhagic fever virus
Crimean-Congo hemorrhagic fever (CCHF) is one of the world’s most medically relevant tick-borne viral diseases. The CCHF virus (CCHFV) is transmitted in seasonal cycles among ticks and animals and is endemic to the Eastern ... -
Epigenetic Modulation of Synaptic Resilience in Alzheimer’s Disease
Some individuals, here referred to as Non-Demented with Alzheimer’s Neuropathology (NDAN), retain their cognitive function despite the presence of amyloid plaques and tau tangles typical of symptomatic Alzheimer’s Disease ... -
Hyperinflammatory Experimental Cerebral Malaria: Coagulation and Glial Cell Activation in Plasmodium chabaudi Infection of IL-10-deficient Mice
Cerebral malaria is one of the most severe complications of Plasmodium falciparum infection and occurs mostly in young African children. This syndrome results from a combination of high levels of parasitemia and inflammation. ... -
“Effect of a meditation-based strategy on sleep quality and perceived stress of healthy older adults living in the community.”
The study assessed the comparative effectiveness of two nonpharmacological interventions, Mantram, a meditation-based strategy, and sleep techniques, to improve sleep in the healthy older adults living in the community. ... -
Pain, Disablement Process and Frailty among Older Adults in the United States: Findings from the National Health and Aging Trends Study
Background: Musculoskeletal pain is highly prevalent among older adults and the most common cause of disability. Objectives: To examine 1) whether sociodemographic characteristics, comorbidities, depression, obesity and ... -
Effect of Severe Burn Injury on Body Composition and Muscle Metabolism in Pediatric Patients
Muscle wasting in burn injury is associated with increased morbidity and mortality. Burn-induced muscle cachexia is partly attributed to lack of physical activity imposed by standard of care. Moreover, evidence supports ... -
Curriculum Vitae
(2019) -
Bubonic Plague Galveston graph
(1920) -
Rat Trappers
(1920)