DSpace at UTMB: Recent submissions
Now showing items 21-40 of 10935
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Scrub typhus: Epidemiology, Diagnosis, Treatment, Prevention and Control in the Asia-Pacific Area and Worldwide
The long term goal of this study is to develop effective measures to control and even eradicate scrub typhus and other related infectious diseases. Scrub typhus is a serious public health problem in the Asia-Pacific area. ... -
Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
Voltage-gated sodium (Nav) channels are responsible for initiation and propagation of action potentials, which contribute to control of neuronal excitability. Malfunction of specific Nav channel isoforms is associated with ... -
Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
CD8+ T cells play a central role in immunity against intracellular pathogens and cancer.Vaccines that elicit robust CD8+ T cell responses are desirable for protection against such infectious diseases and cancers. Subunit ... -
DELINEATING REGULATORY PATHWAYS OF NOVEL CANCER STEM CELL MARKER, DCLK1-S, FOR TARGETING COLON CANCER STEM CELLS
Colon cancer is third most prevalent cancer in the United States, with significant health consequences for the patient and society. Cancer stem cells are believed to be resistant to conventional treatments resulting in ... -
EMOTIONAL HEALTH AND TEENAGE PREGNANCY IN GALVESTON INDEPENDENT SCHOOL DISTRICT HIGHSCHOOLERS
In Galveston County in 2011 there were 15.9 live births per 1000 girls aged 15-17 years old, which is higher than the national average. The purpose of this research was to assess the role of emotional health, specifically ... -
Comparison of current evidence from randomized clinical trials and observational studies for immunogenicity in variable meningococcal C vaccine schedules in children, adolescents, and adults
Even as early as age 10, older age correlated with increased duration of protection. Seroprotective antibody titers in infants were short-lived after primary schedule vaccinations were completed, and by 12 months of age, ... -
Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
Chronic pancreatitis (CP) is an irreversible disease process defined by acinar cell necrosis, inflammation and fibrosis. With disease progression, patients develop pancreatic insufficiency secondary to the destruction of ... -
Food Allergy Risk Mitigation in Texas Independent School Districts
An estimated 4%-6% of American school children attending federal, state, early care and education programs are affected by food allergies. Allergic reactions can be life threatening, with resultant far reaching impact on ... -
Genotypic and Molecular Determinants in the Continued Evolution of West Nile Virus in the United States
Following the introduction of West Nile virus (WNV) into New York in 1999, the virus continues to evolve in the U.S. with the emergence, extinction, and co-circulation of multiple, distinct U.S. genotypes. Despite annual ... -
Relative Contributions of Complications and Failure to Rescue on Mortality in Older Patients Undergoing Pancreatectomy
OBJECTIVE AND SUMMARY BACKGROUND DATA: For pancreatectomy patients, mortality increases with increasing age. Our study evaluated the relative contribution of overall postoperative complications and failure to rescue rates ... -
Relative Contributions of Complications and Failure to Rescue on Mortality in Older Patients Undergoing Pancreatectomy
OBJECTIVE AND SUMMARY BACKGROUND DATA: For pancreatectomy patients, mortality increases with increasing age. Our study evaluated the relative contribution of overall postoperative complications and failure to rescue rates ... -
Cross-Cultural Views of Dementia: A Focus on African Americans, Asians, Caucasians and Hispanics
Dementia affects about 5,000,000 Americans and unfortunately this number will only continue to rise as the United States (US) population ages. It is a financially burdening disease, costing billions of dollars and hundreds ... -
Genetic Determinants of ABCB1 Promoter Activity and Their Effects on Environmental Exposure
In utero exposure to xenobiotics, including medications and environmental agents, can lead to developmental and behavioral problems as well as cancer later in life. Efflux transporters, which are highly expressed in the ... -
Effectiveness of a Fall Prevention Educational Program for Long-Term Care Nursing Staff
The goal of the research study was to evaluate the impact of an educational intervention on falls in a long-term care facility by (a) measuring staff knowledge of fall prevention, (b) behavioral assessment of fall prevention ... -
Maternal Reflective Functioning, Parental Beliefs, and Parenting Stress of Mothers in a Residential Treatment Program
Maternal Reflective Functioning, Parental Beliefs, and Parenting Stress of Mothers in a Residential Treatment Program Kathleen Pitts, PhD The University of Texas Medical Branch, 2017 Mothers with a history of substance-use ... -
Social Support and Viral Reactivation in US and Foreign-Born Mexican Americans
Social support may explain a part of the Hispanic Paradox, the persistent pattern of mortality outcomes for low-SES Hispanic Americans that more closely compare to higher-SES Caucasians than lower-SES African Americans. ... -
UNDERSTANDING AND MODULATING MACROPHAGE METABOLISM FOR IMPROVING INFLAMMATORY FUNCTIONS AGAINST TRYPANOSOMA CRUZI INFECTION
This dissertation aims to illuminate how metabolism regulates the pro-inflammatory functions in macrophages for improving the clearance of Trypanosoma cruzi infection. T. cruzi is the etiologic agent of Chagas disease, ... -
Biophysical mechanisms of intrinsic protein disorder: lessons from a protein backbone model
Intrinsically disordered regions (IDRs) in proteins populate a dynamic, heterogenous ensemble of structures. Proteins involved in the regulation of critical cellular functions rely on IDRs to carry out their functions. ... -
Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Cystathionine β synthase (CBS) is a hydrogen sulfide producing enzyme that catalyzes the first step of the transsulfuration pathway converting homocysteine to cystathionine. CBS and the subsequent production of H2S are ... -
The Activation of the Inflammasome during Rickettsial Infection
Rickettsiae are Gram-negative, obligately intracellular bacteria that infect endothelial cells and macrophages. The molecular mechanisms involved in interaction of rickettsiae with macrophages, however, remain poorly ...