Noninvasive optoacoustic monitoring of blood oxygenation in large blood vessels

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dc.contributor.advisorRinat Esenalieven_US
dc.contributor.committeeMemberStanislav Emelianoven_US
dc.contributor.committeeMemberMassoud motamedien_US
dc.contributor.committeeMemberHarvey Fishmanen_US
dc.contributor.committeeMemberGracie vargasen_US
dc.creatorHans-Peter Franz Brechten_US
dc.date.accessioned2011-12-20T16:05:38Z
dc.date.available2008-06-17en_US
dc.date.available2011-12-20T16:05:38Z
dc.date.created2007-11-25en_US
dc.date.issued2007-09-19en_US
dc.description.abstractContinuous monitoring of cerebral blood oxygenation is critically important for successful treatment of patients with severe traumatic brain injury and patients undergoing cardiac surgery. At present, the techniques for monitoring blood oxygenation are invasive. We propose the noninvasive monitoring of cerebral venous blood hemoglobin saturation (SvO2) by optoacoustic probing of blood circulating in the internal jugular vein (IJV). This thesis describes the tests of the optoacoustic system with three different probes in phantoms, in vitro, and in vivo in sheep along with different data processing algorithms. A LabView®-based scanning system, that automatically moves the optoacoustic probe across the IJV while continuously taking measurements, was developed and used for testing the optoacoustic probes. Automatic signal processing determined the signal with the best probe-vessel alignment which was then used for further processing. The scanning system was tested in phantoms using solutions with different absorption coefficients and with blood at various levels of hemoglobin saturation (SO2). Amplitudes and profiles of the optoacoustic signals recorded from the phantoms closely followed the SO2 changes in accordance with blood optical properties. These data indicate that the scanning system is capable of improving the accuracy of noninvasive monitoring of hemoglobin saturation by minimizing errors associated with lateral misalignment of the probe with respect to blood vessels.en_US
dc.format.mediumelectronicen_US
dc.identifier.otheretd-11252007-204524en_US
dc.identifier.urihttp://hdl.handle.net/2152.3/272
dc.language.isoengen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjectoptoacousticen_US
dc.subjectnoninvasiveen_US
dc.subjectmonitoringen_US
dc.subjectlarge blood vesselsen_US
dc.subjectblood oxygenationen_US
dc.titleNoninvasive optoacoustic monitoring of blood oxygenation in large blood vesselsen_US
dc.type.genredissertationen_US
dc.type.materialtexten_US
thesis.degree.departmentBiochemistry and Molecular Biologyen_US
thesis.degree.grantorThe University of Texas Medical Branchen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePhDen_US

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