Towards the rational design of mechanical proteins

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dc.contributor.advisorKrishna Rajarathnamen_US
dc.contributor.committeeMemberWolfgang Obermannen_US
dc.contributor.committeeMemberWlodzimierz Bujalowskien_US
dc.contributor.committeeMemberWerner Braunen_US
dc.contributor.committeeMemberR. Bryan Suttonen_US
dc.contributor.committeeMemberB. Montgomery Pettitten_US
dc.contributor.committeeMemberAndres F. Oberhauseren_US
dc.creatorTzintzuni Garciaen_US
dc.date.accessioned2011-12-20T16:04:39Z
dc.date.available2010-09-28en_US
dc.date.available2011-12-20T16:04:39Z
dc.date.created2009-04-27en_US
dc.date.issued2009-04-23en_US
dc.description.abstractThe biological functions of proteins have long been studied in a manner that has deprived us of a basic mode of inquiry: physical manipulation. In recent years theoretical and technological advances have made possible tools to directly manipulate single molecules mechanically. The atomic force microscope is a flexible and robust platform that allows us this ability. At the same time computational tools have become increasingly common companions and facilitators of theoretical and experimental science. Of the many mechanically important proteins titin and titin-like proteins are important on many levels. From a physiological understanding of the way mechanical strength is propagated from sarcomere to muscle tissue, to a theoretical understanding of the molecular mechanisms contributing to the mechanical design of proteins in general. We have used a combination of computational techniques on a basis of experimental evidence to make predictions and then test them experimentally to ultimately grow our body of knowledge concerning the mechanical design of proteins.en_US
dc.format.mediumelectronicen_US
dc.identifier.otheretd-04272009-144054en_US
dc.identifier.urihttp://hdl.handle.net/2152.3/104
dc.language.isoengen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjecttitinen_US
dc.subjectsingle moleculeen_US
dc.subjectphysical chemical propertiesen_US
dc.subjectpcpmeren_US
dc.subjectmotifen_US
dc.subjectmechanicalen_US
dc.subjectimmunoglobulin-likeen_US
dc.subjectigen_US
dc.subjectatomic force microscopeen_US
dc.subjectafmen_US
dc.titleTowards the rational design of mechanical proteinsen_US
dc.type.genredissertationen_US
dc.type.materialtexten_US
thesis.degree.departmentBiochemistry and Molecular Biologyen_US
thesis.degree.grantorThe University of Texas Medical Branchen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePhDen_US

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