Longitudinal Visualization of Neurodegeneration: Digital Biopsy of the Retina

dc.creatorLuisi, Jonathan David
dc.creator.orcid0000-0002-4900-6820
dc.date.accessioned2022-05-10T17:45:34Z
dc.date.available2022-05-10T17:45:34Z
dc.date.created2019-05
dc.date.submittedMay 2019
dc.date.updated2022-05-10T17:45:36Z
dc.description.abstractAs treatment for most retinal diseases only begins after vision impairing degeneration is detectable, a better understanding of what changes lead to neurodegeneration is required. Due to the isolated physiology of the eye, the classical markers of inflammation are not detectable in-vivo without an invasive biopsy. The major aims of this dissertation are to explore optical methods for a digital biopsy and demonstrate their utility in animal models of disease. In this dissertation, traditional ophthalmology methods were augmented with emerging optical techniques and biological markers to track inflammatory progression in different disease models.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152.3/11430
dc.subjectOphthalmology
dc.subjectRetina Degeneration
dc.subjectOptical Coherence Tomography Angiography
dc.subjectMicroglia
dc.subjectExosomes
dc.titleLongitudinal Visualization of Neurodegeneration: Digital Biopsy of the Retina
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentPharmacology and Toxicology
thesis.degree.grantorThe University of Texas Medical Branch at Galveston
thesis.degree.levelDoctoral
thesis.degree.namePharmacology and Toxicology (Doctoral)

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