A thermodynamic definition of protein folds

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dc.contributor.advisorRobert Foxen_US
dc.contributor.committeeMemberWlodek Bujalowskien_US
dc.contributor.committeeMemberVincent Hilseren_US
dc.contributor.committeeMemberMontgomery Pettitten_US
dc.contributor.committeeMemberHenry Epsteinen_US
dc.creatorJason Vertreesen_US
dc.date.accessioned2011-12-20T16:04:41Z
dc.date.available2008-06-17en_US
dc.date.available2011-12-20T16:04:41Z
dc.date.created2008-05-13en_US
dc.date.issued2008-05-01en_US
dc.description.abstractModern techniques in structural biology, like homology modeling, protein threading, protein fold classification, and homology detection have proven extremely useful. For example, they have provided us with evolutionary information about protein homology which has in some many cases lead directly to therapeutics. Due to the importance of these methods, augmenting or improving them may lead to significant advances in understanding proteins. These methods treat the high-resolution structure as a static entity upon which they operate, however we know that proteins are not static entities---they are polymers that exist in an enormous array of conformational states. Therefore, we propose to model the proteins from a statistical thermodynamic viewpoint based upon their average energetic properties. We show that this model can be used to (1) better characterize the partial unfolding process of proteins, and (2) reclassify the protein fold space from a new perspective.en_US
dc.format.mediumelectronicen_US
dc.identifier.otheretd-05132008-091250en_US
dc.identifier.urihttp://hdl.handle.net/2152.3/110
dc.language.isoengen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjectthermodynamicsen_US
dc.subjectSVDen_US
dc.subjectstructural thermodynamicsen_US
dc.subjectstatistical thermodynamicsen_US
dc.subjectremote homologyen_US
dc.subjectprotein foldsen_US
dc.subjectprotein fold classificationen_US
dc.subjectPCAen_US
dc.subjectensembleen_US
dc.subjectCOREXen_US
dc.titleA thermodynamic definition of protein foldsen_US
dc.type.genredissertationen_US
dc.type.materialtexten_US
thesis.degree.departmentBiochemistry and Molecular Biologyen_US
thesis.degree.grantorThe University of Texas Medical Branchen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePhDen_US

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