HIGH TRAIT MOTOR IMPULSIVITY IS AN ANTECEDENT TO COCAINE-SEEKING BUT NOT OXYCODONE-SEEKING BEHAVIOR IN RODENTS

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dc.creatorCampbell, Veronica M
dc.date.accessioned2022-08-05T15:10:08Z
dc.date.available2022-08-05T15:10:08Z
dc.date.created2019-08
dc.date.submittedAugust 2019
dc.date.updated2022-08-05T15:10:09Z
dc.description.abstractRelapse is a dynamic and essential barrier to abstinence in substance use disorders with behavioral endophenotypes (e.g. impulsivity) and exposure to environmental drug-associated cues along with complex neurobiology as precipitating factors. Impulsivity is expressed in different forms (e.g. motor impulsivity, impulsive choice) and is associated with both cocaine use disorder and opioid use disorder. Animal models of motor impulsivity and relapse vulnerability can be reasonably matched to provide valid translational approaches to help determine whether motor impulsivity is a factor leading to (i.e., trait) and/or resulting from abstinence from (i.e., state) drug use and relapse. We tested the hypotheses that abstinence from cocaine and oxycodone would have differential effects on trait motor impulsivity and drug-seeking behavior. We demonstrate that oxycodone- but not cocaine-abstinence altered trait motor impulsivity phenotypes. Additionally, motor impulsivity phenotypes predicted cocaine but not oxycodone drug-seeking. The findings presented here offer a glimpse into the complex relationship between trait and state motor impulsivity and drug-seeking behaviors during abstinence across classes of drugs of abuse.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152.3/11590
dc.subjectCocaine
dc.subjectoxycodone
dc.subjectmotor impulsivity
dc.subjectrelapse
dc.subjectself-administration
dc.subject1-CSRT task
dc.subjectopioids
dc.subjecttrait
dc.subjectstate
dc.titleHIGH TRAIT MOTOR IMPULSIVITY IS AN ANTECEDENT TO COCAINE-SEEKING BUT NOT OXYCODONE-SEEKING BEHAVIOR IN RODENTS
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentPharmacology and Toxicology
thesis.degree.grantorThe University of Texas Medical Branch at Galveston
thesis.degree.levelMasters
thesis.degree.namePharmacology and Toxicology (Masters)

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